Intragastric and intraoesophagel pH monitoring in duodenal ulcer patients: effect of the new histamine H2-receptor antagonist ramixotidine

M. Molgora, G. Basilisco, A. Bozzani, G. Camboni, P. A. Bianchi

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of the new histamine H2-receptor antagonist ramixotidine 750 mg p.o., administered at 22.00 h, on intragastric and intraoesophageal pH monitored from 22.00 h to 08.00 h, was studied in a double-blind cross-over trial in 11 duodenal ulcer patients. Placebo and ramixotidine were given to each patient on 2 consecutive days in a randomized sequence. Three patients were excluded from the intragastric pH analysis as the records on the second study day were technically inadequate. No significant carry-over or sequence effect was noted. Intragastric hydrogen ion activity was significantly lower (p=0.01) after ramixotidine than after placebo: median (range) 24 (9-100) vs 97 (27-188) mmol/l. The percentage of time with intraoesophageal pH

Original languageEnglish
Pages (from-to)405-407
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Volume37
Issue number4
DOIs
Publication statusPublished - Jul 1989

Keywords

  • duodenal ulcer
  • gastro-oesophageal reflux
  • histamine H-antagonist
  • intragastric pH monitoring
  • oesophagitis
  • ramixotidine

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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