Abstract
The effect of the new histamine H2-receptor antagonist ramixotidine 750 mg p.o., administered at 22.00 h, on intragastric and intraoesophageal pH monitored from 22.00 h to 08.00 h, was studied in a double-blind cross-over trial in 11 duodenal ulcer patients. Placebo and ramixotidine were given to each patient on 2 consecutive days in a randomized sequence. Three patients were excluded from the intragastric pH analysis as the records on the second study day were technically inadequate. No significant carry-over or sequence effect was noted. Intragastric hydrogen ion activity was significantly lower (p=0.01) after ramixotidine than after placebo: median (range) 24 (9-100) vs 97 (27-188) mmol/l. The percentage of time with intraoesophageal pH
Original language | English |
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Pages (from-to) | 405-407 |
Number of pages | 3 |
Journal | European Journal of Clinical Pharmacology |
Volume | 37 |
Issue number | 4 |
DOIs | |
Publication status | Published - Jul 1989 |
Keywords
- duodenal ulcer
- gastro-oesophageal reflux
- histamine H-antagonist
- intragastric pH monitoring
- oesophagitis
- ramixotidine
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology (medical)