Intrahepatic Administration of Amphotericin B Liposomal (Ambisome®) for the Management of a Liver Abscess from Candida albicans in a preterm infant

Cinzia Auriti, Maria Paola Ronchetti, Iliana Bersani, Fabrizio Gennari, Fiammetta Piersigilli

Research output: Contribution to journalArticle

Abstract

Hepatic fungal abscesses are rare in the neonatal period and often constitute a severe complication of the catheterization of the umbilical vessels. Such life-threatening lesions are observed more frequently in preterm than in other newborn infants and the optimal treatment remains uncertain. We present the case of a preterm neonate, who developed an intrahepatic lesion due to parenteral extravasation, successively contaminated by Candida albicans Despite the maximal pharmacological therapies, the treatment that led to the definitive resolution of the abscess was the placement of a surgical drainage followed by the direct intralesional administration of liposomal amphotericin B (AmBisome), never described in neonates in the literature, which turned out to be a safe and effective approach.

Original languageEnglish
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
DOIs
Publication statusE-pub ahead of print - Sep 17 2018

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Liver Abscess
Candida albicans
Premature Infants
Newborn Infant
Umbilicus
Catheterization
Abscess
Drainage
Therapeutics
Pharmacology
liposomal amphotericin B

Cite this

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title = "Intrahepatic Administration of Amphotericin B Liposomal (Ambisome{\circledR}) for the Management of a Liver Abscess from Candida albicans in a preterm infant",
abstract = "Hepatic fungal abscesses are rare in the neonatal period and often constitute a severe complication of the catheterization of the umbilical vessels. Such life-threatening lesions are observed more frequently in preterm than in other newborn infants and the optimal treatment remains uncertain. We present the case of a preterm neonate, who developed an intrahepatic lesion due to parenteral extravasation, successively contaminated by Candida albicans Despite the maximal pharmacological therapies, the treatment that led to the definitive resolution of the abscess was the placement of a surgical drainage followed by the direct intralesional administration of liposomal amphotericin B (AmBisome), never described in neonates in the literature, which turned out to be a safe and effective approach.",
author = "Cinzia Auriti and Ronchetti, {Maria Paola} and Iliana Bersani and Fabrizio Gennari and Fiammetta Piersigilli",
note = "Copyright {\circledC} 2018 American Society for Microbiology.",
year = "2018",
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doi = "10.1128/AAC.01239-18",
language = "English",
journal = "Antimicrobial Agents and Chemotherapy",
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T1 - Intrahepatic Administration of Amphotericin B Liposomal (Ambisome®) for the Management of a Liver Abscess from Candida albicans in a preterm infant

AU - Auriti, Cinzia

AU - Ronchetti, Maria Paola

AU - Bersani, Iliana

AU - Gennari, Fabrizio

AU - Piersigilli, Fiammetta

N1 - Copyright © 2018 American Society for Microbiology.

PY - 2018/9/17

Y1 - 2018/9/17

N2 - Hepatic fungal abscesses are rare in the neonatal period and often constitute a severe complication of the catheterization of the umbilical vessels. Such life-threatening lesions are observed more frequently in preterm than in other newborn infants and the optimal treatment remains uncertain. We present the case of a preterm neonate, who developed an intrahepatic lesion due to parenteral extravasation, successively contaminated by Candida albicans Despite the maximal pharmacological therapies, the treatment that led to the definitive resolution of the abscess was the placement of a surgical drainage followed by the direct intralesional administration of liposomal amphotericin B (AmBisome), never described in neonates in the literature, which turned out to be a safe and effective approach.

AB - Hepatic fungal abscesses are rare in the neonatal period and often constitute a severe complication of the catheterization of the umbilical vessels. Such life-threatening lesions are observed more frequently in preterm than in other newborn infants and the optimal treatment remains uncertain. We present the case of a preterm neonate, who developed an intrahepatic lesion due to parenteral extravasation, successively contaminated by Candida albicans Despite the maximal pharmacological therapies, the treatment that led to the definitive resolution of the abscess was the placement of a surgical drainage followed by the direct intralesional administration of liposomal amphotericin B (AmBisome), never described in neonates in the literature, which turned out to be a safe and effective approach.

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DO - 10.1128/AAC.01239-18

M3 - Article

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

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