Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: A case-control study in Italy

Francesco Donato, Umberto Gelatti, Alessandro Tagger, Maurizio Favret, Maria Lisa Ribero, Francesco Callea, Claudia Martelli, Antonella Savio, Paola Trevisi, Giuseppe Nardi

Research output: Contribution to journalArticle

Abstract

Objective: Intrahepatic cholangiocarcinoma (ICC) is a rare type of primary liver cancer (PLC) arising from intrahepatic bile ducts. We carried out a case-control study to assess the association between ICC and hepatitis B and C virus (HBV and HCV) infections, alcohol intake, and hepatolithiasis in Brescia, North Italy. Methods: Among 370 subjects with histology-based diagnosis of PLC who were resident in the area and hospitalized in 1995-2000, 26 (7%) ICC cases were identified. A total of 824 subjects unaffected by hepatic diseases and frequency-matched with PLC cases by age, sex, date, and hospital of admission were recruited as controls. Results: Among ICC cases the mean age was 65 years, 80.8% were males, and 38.5% had cirrhosis. Seropositivity for anti-HCV, HBsAg, alcohol intake > 80 g/day and history of hepatolithiasis were found in 25%, 13%, 23.1%, and 26.9% of ICC cases and in 5.8%, 6.7%, 32.9%, and 10.6% of controls, respectively. The odds ratios adjusted for demographic factors by logistic regression (95% confidence interval; 95% CI) were 9.7 (1.6-58.9) for anti-HCV, 2.7 (0.4-18.4) for HBsAg, and 6.7 (1.3-33.4) for hepatolithiasis, whereas no association was found with alcohol drinking. Conclusions: HCV and hepatolithiasis may be risk factors for ICC in Western countries.

Original languageEnglish
Pages (from-to)959-964
Number of pages6
JournalCancer Causes and Control
Volume12
Issue number10
DOIs
Publication statusPublished - 2001

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Cholangiocarcinoma
Virus Diseases
Hepatitis B virus
Hepacivirus
Italy
Case-Control Studies
Alcohols
Liver Neoplasms
Hepatitis B Surface Antigens
Intrahepatic Bile Ducts
Alcohol Drinking
Histology
Fibrosis
Logistic Models
Odds Ratio
Demography
Confidence Intervals
Liver
Infection

Keywords

  • Hepatitis B virus
  • Hepatitis C virus
  • Hepatolithiasis
  • Intrahepatic cholangiocarcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Epidemiology
  • Oncology

Cite this

Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis : A case-control study in Italy. / Donato, Francesco; Gelatti, Umberto; Tagger, Alessandro; Favret, Maurizio; Ribero, Maria Lisa; Callea, Francesco; Martelli, Claudia; Savio, Antonella; Trevisi, Paola; Nardi, Giuseppe.

In: Cancer Causes and Control, Vol. 12, No. 10, 2001, p. 959-964.

Research output: Contribution to journalArticle

Donato, F, Gelatti, U, Tagger, A, Favret, M, Ribero, ML, Callea, F, Martelli, C, Savio, A, Trevisi, P & Nardi, G 2001, 'Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: A case-control study in Italy', Cancer Causes and Control, vol. 12, no. 10, pp. 959-964. https://doi.org/10.1023/A:1013747228572
Donato, Francesco ; Gelatti, Umberto ; Tagger, Alessandro ; Favret, Maurizio ; Ribero, Maria Lisa ; Callea, Francesco ; Martelli, Claudia ; Savio, Antonella ; Trevisi, Paola ; Nardi, Giuseppe. / Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis : A case-control study in Italy. In: Cancer Causes and Control. 2001 ; Vol. 12, No. 10. pp. 959-964.
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abstract = "Objective: Intrahepatic cholangiocarcinoma (ICC) is a rare type of primary liver cancer (PLC) arising from intrahepatic bile ducts. We carried out a case-control study to assess the association between ICC and hepatitis B and C virus (HBV and HCV) infections, alcohol intake, and hepatolithiasis in Brescia, North Italy. Methods: Among 370 subjects with histology-based diagnosis of PLC who were resident in the area and hospitalized in 1995-2000, 26 (7{\%}) ICC cases were identified. A total of 824 subjects unaffected by hepatic diseases and frequency-matched with PLC cases by age, sex, date, and hospital of admission were recruited as controls. Results: Among ICC cases the mean age was 65 years, 80.8{\%} were males, and 38.5{\%} had cirrhosis. Seropositivity for anti-HCV, HBsAg, alcohol intake > 80 g/day and history of hepatolithiasis were found in 25{\%}, 13{\%}, 23.1{\%}, and 26.9{\%} of ICC cases and in 5.8{\%}, 6.7{\%}, 32.9{\%}, and 10.6{\%} of controls, respectively. The odds ratios adjusted for demographic factors by logistic regression (95{\%} confidence interval; 95{\%} CI) were 9.7 (1.6-58.9) for anti-HCV, 2.7 (0.4-18.4) for HBsAg, and 6.7 (1.3-33.4) for hepatolithiasis, whereas no association was found with alcohol drinking. Conclusions: HCV and hepatolithiasis may be risk factors for ICC in Western countries.",
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T1 - Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis

T2 - A case-control study in Italy

AU - Donato, Francesco

AU - Gelatti, Umberto

AU - Tagger, Alessandro

AU - Favret, Maurizio

AU - Ribero, Maria Lisa

AU - Callea, Francesco

AU - Martelli, Claudia

AU - Savio, Antonella

AU - Trevisi, Paola

AU - Nardi, Giuseppe

PY - 2001

Y1 - 2001

N2 - Objective: Intrahepatic cholangiocarcinoma (ICC) is a rare type of primary liver cancer (PLC) arising from intrahepatic bile ducts. We carried out a case-control study to assess the association between ICC and hepatitis B and C virus (HBV and HCV) infections, alcohol intake, and hepatolithiasis in Brescia, North Italy. Methods: Among 370 subjects with histology-based diagnosis of PLC who were resident in the area and hospitalized in 1995-2000, 26 (7%) ICC cases were identified. A total of 824 subjects unaffected by hepatic diseases and frequency-matched with PLC cases by age, sex, date, and hospital of admission were recruited as controls. Results: Among ICC cases the mean age was 65 years, 80.8% were males, and 38.5% had cirrhosis. Seropositivity for anti-HCV, HBsAg, alcohol intake > 80 g/day and history of hepatolithiasis were found in 25%, 13%, 23.1%, and 26.9% of ICC cases and in 5.8%, 6.7%, 32.9%, and 10.6% of controls, respectively. The odds ratios adjusted for demographic factors by logistic regression (95% confidence interval; 95% CI) were 9.7 (1.6-58.9) for anti-HCV, 2.7 (0.4-18.4) for HBsAg, and 6.7 (1.3-33.4) for hepatolithiasis, whereas no association was found with alcohol drinking. Conclusions: HCV and hepatolithiasis may be risk factors for ICC in Western countries.

AB - Objective: Intrahepatic cholangiocarcinoma (ICC) is a rare type of primary liver cancer (PLC) arising from intrahepatic bile ducts. We carried out a case-control study to assess the association between ICC and hepatitis B and C virus (HBV and HCV) infections, alcohol intake, and hepatolithiasis in Brescia, North Italy. Methods: Among 370 subjects with histology-based diagnosis of PLC who were resident in the area and hospitalized in 1995-2000, 26 (7%) ICC cases were identified. A total of 824 subjects unaffected by hepatic diseases and frequency-matched with PLC cases by age, sex, date, and hospital of admission were recruited as controls. Results: Among ICC cases the mean age was 65 years, 80.8% were males, and 38.5% had cirrhosis. Seropositivity for anti-HCV, HBsAg, alcohol intake > 80 g/day and history of hepatolithiasis were found in 25%, 13%, 23.1%, and 26.9% of ICC cases and in 5.8%, 6.7%, 32.9%, and 10.6% of controls, respectively. The odds ratios adjusted for demographic factors by logistic regression (95% confidence interval; 95% CI) were 9.7 (1.6-58.9) for anti-HCV, 2.7 (0.4-18.4) for HBsAg, and 6.7 (1.3-33.4) for hepatolithiasis, whereas no association was found with alcohol drinking. Conclusions: HCV and hepatolithiasis may be risk factors for ICC in Western countries.

KW - Hepatitis B virus

KW - Hepatitis C virus

KW - Hepatolithiasis

KW - Intrahepatic cholangiocarcinoma

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