Intrahepatic fluorodeoxyuridine to treat unresectable hepatocellular carcinoma patients

Giuseppe Nastasi, Camillo Porta, Mauro Moroni, Mario Alessiani, Giansilvio Fossati

Research output: Contribution to journalArticle

Abstract

Of 16 HCC patients who received intrahepatic FdUrd at a dose of 0.3 mg/kg/day for 14 consecutive days by continuous infusion, every 28 days, no one achieved a complete response, while 3 patients achieved partial response (18.75%), lasting 6, 9 and 18 months, respectively. Seven patients (43.5%) exhibited stable disease and their mean time to progression was 4.28 months; in the extant 6 patients (37.5%) the disease progressed. Major biliary toxicity was observed. On the basis of these data, intra-arterial chemotherapy should not yet be considered the standard treatment of unresectable HCCs.

Original languageEnglish
Pages (from-to)511-514
Number of pages4
JournalOncology Reports
Volume4
Issue number3
Publication statusPublished - May 1997

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Floxuridine
Hepatocellular Carcinoma
Drug Therapy

Keywords

  • fluorodeoxyuridine
  • hepatocellular carcinoma
  • intrahepatic chemotherapy
  • phase-II study

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Nastasi, G., Porta, C., Moroni, M., Alessiani, M., & Fossati, G. (1997). Intrahepatic fluorodeoxyuridine to treat unresectable hepatocellular carcinoma patients. Oncology Reports, 4(3), 511-514.

Intrahepatic fluorodeoxyuridine to treat unresectable hepatocellular carcinoma patients. / Nastasi, Giuseppe; Porta, Camillo; Moroni, Mauro; Alessiani, Mario; Fossati, Giansilvio.

In: Oncology Reports, Vol. 4, No. 3, 05.1997, p. 511-514.

Research output: Contribution to journalArticle

Nastasi, G, Porta, C, Moroni, M, Alessiani, M & Fossati, G 1997, 'Intrahepatic fluorodeoxyuridine to treat unresectable hepatocellular carcinoma patients', Oncology Reports, vol. 4, no. 3, pp. 511-514.
Nastasi G, Porta C, Moroni M, Alessiani M, Fossati G. Intrahepatic fluorodeoxyuridine to treat unresectable hepatocellular carcinoma patients. Oncology Reports. 1997 May;4(3):511-514.
Nastasi, Giuseppe ; Porta, Camillo ; Moroni, Mauro ; Alessiani, Mario ; Fossati, Giansilvio. / Intrahepatic fluorodeoxyuridine to treat unresectable hepatocellular carcinoma patients. In: Oncology Reports. 1997 ; Vol. 4, No. 3. pp. 511-514.
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