Intrahepatic vascular changes in non-alcoholic fatty liver disease: Potential role of insulin-resistance and endothelial dysfunction

Marcos Pasarin, Juan G. Abraldes, Eleonora Liguori, Beverley Kok, Vincenzo La Mura

Research output: Contribution to journalReview articlepeer-review

Abstract

Metabolic syndrome is a cluster of several clinical conditions characterized by insulin-resistance and high cardiovascular risk. Non-alcoholic fatty liver disease is the liver expression of the metabolic syndrome, and insulin resistance can be a frequent comorbidity in several chronic liver diseases, in particular hepatitis C virus infection and/or cirrhosis. Several studies have demonstrated that insulin action is not only relevant for glucose control, but also for vascular homeostasis. Insulin regulates nitric oxide production, which mediates to a large degree the vasodilating, antiinflammatory and antithrombotic properties of a healthy endothelium, guaranteeing organ perfusion. The effects of insulin on the liver microvasculature and the effects of IR on sinusoidal endothelial cells have been studied in animal models of non-alcoholic fatty liver disease. The hypotheses derived from these studies and the potential translation of these results into humans are critically discussed in this review.

Original languageEnglish
Pages (from-to)6777-6787
Number of pages11
JournalWorld Journal of Gastroenterology
Volume23
Issue number37
DOIs
Publication statusPublished - Oct 7 2017

Keywords

  • Endothelial dysfunction
  • Insulin resistance
  • Metabolic syndrome
  • Non-alcoholic fatty liver disease

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint

Dive into the research topics of 'Intrahepatic vascular changes in non-alcoholic fatty liver disease: Potential role of insulin-resistance and endothelial dysfunction'. Together they form a unique fingerprint.

Cite this