Intraindividual comparison of gadoxetate disodium - Enhanced MR imaging and 64-section multidetector CT in the detection of hepatocellular carcinoma in patients with cirrhosis

Michele Di Martino, Daniele Marin, Antonino Guerrisi, Mahbubeh Baski, Francesca Galati, Massimo Rossi, Stefania Brozzetti, Raffaele Masciangelo, Roberto Passariello, Carlo Catalano

Research output: Contribution to journalArticle

Abstract

Purpose: To prospectively compare gadoxetate disodium-enhanced magnetic resonance (MR) imaging with multiphasic 64-section multidetector computed tomography (CT) in the detection of hepatocellular carcinoma (HCC) in patients with cirrhosis. Materials and Methods: Institutional review board approval and informed patient consent were obtained for this prospective study. Fifty-eight patients (39 men, 19 women;mean age, 63 years;age range, 35-84 years) underwent gadoxetate disodium-enhanced MR imaging and multiphasic 64-section multidetector CT. The imaging examinations were performed within 30 days of each other. The two sets of images were qualitatively analyzed in random order by three independent readers in a blinded and retrospective fashion. Using strict diagnostic criteria for HCC, readers classified all detected lesions with use of a four-point confidence scale. The reference standard was a combination of pathologic proof, conclusive imaging findings, and substantial tumor growth at follow-up CT or MR imaging (range of follow-up, 90-370 days). The diagnostic accuracy, sensitivity, and positive predictive value were compared between the two image sets. Interreader variability was assessed. The accuracy of each imaging method was determined by using an adjusted modified X2 test. Results: Eighty-seven HCCs (mean size ± standard deviation, 1.8 cm ± 1.5; range, 0.3-7.0 cm) were confirmed in 42 of the 58 patients. Regardless of lesion size, the average diagnostic accuracy and sensitivity for all readers were significantly greater with gadoxetate disodium-enhanced MR imaging (average diagnostic accuracy: 0.88, 95% confidence interval [CI]: 0.80, 0.97; average sensitivity: 0.85, 95% CI: 0.74, 0.96) than with multidetector CT (average diagnostic accuracy: 0.74, 95% CI: 0.65, 0.82; average sensitivity: 0.69, 95% CI: 0.59, 0.79) (P

Original languageEnglish
Pages (from-to)806-816
Number of pages11
JournalRadiology
Volume256
Issue number3
DOIs
Publication statusPublished - Sep 2010

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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