VARIABILITA INTRAINDIVIDUALE DEI LIVELLI BASALI DELLA CICLOSPORINA ED EFFICACIA DELLA IMMUNODEPRESSIONE

Translated title of the contribution: Intraindividual variability of cyclosporine blood levels and its effects on patient's immunosuppression

A. Elli, P. Palazzi, F. Nicosia, S. Zafiropulu, S. Tedeschi, F. Quarto Di Palo

Research output: Contribution to journalArticle

Abstract

We evaluated mean cyclosporine (CSA) level and its variation coefficient (CVC) in 100 non-immunized recipients of cadaver renal transplants over a five-year period. The mean intraindividual variability of CSA blood levels was 25.3% (min 5%, max 71%) with a median value of 27.7%. Patients were divided into two groups (Group A: CVC 28%) and both groups were compared for graft function and survival. Patients of Group A showed stability in renal function and only 10.5% of the grafts were lost for rejection. In patients of Group B plasma creatinine levels increased from 122 ± 3.8 to 179 ± 11.5 μM/l over the five-year period of the study (p <0.001); creatinine clearance decreased (p <0.05) and a greater graft loss (31.9%) was observed. In conclusion, an elevated intraindividual variability of CSA through blood levels was associated with increased risk of renal function deterioration and graft loss.

Translated title of the contributionIntraindividual variability of cyclosporine blood levels and its effects on patient's immunosuppression
Original languageItalian
Pages (from-to)269-273
Number of pages5
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume12
Issue number4
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'Intraindividual variability of cyclosporine blood levels and its effects on patient's immunosuppression'. Together they form a unique fingerprint.

  • Cite this