We evaluated mean cyclosporine (CSA) level and its variation coefficient (CVC) in 100 non-immunized recipients of cadaver renal transplants over a five-year period. The mean intraindividual variability of CSA blood levels was 25.3% (min 5%, max 71%) with a median value of 27.7%. Patients were divided into two groups (Group A: CVC 28%) and both groups were compared for graft function and survival. Patients of Group A showed stability in renal function and only 10.5% of the grafts were lost for rejection. In patients of Group B plasma creatinine levels increased from 122 ± 3.8 to 179 ± 11.5 μM/l over the five-year period of the study (p <0.001); creatinine clearance decreased (p <0.05) and a greater graft loss (31.9%) was observed. In conclusion, an elevated intraindividual variability of CSA through blood levels was associated with increased risk of renal function deterioration and graft loss.
|Translated title of the contribution||Intraindividual variability of cyclosporine blood levels and its effects on patient's immunosuppression|
|Number of pages||5|
|Journal||Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia|
|Publication status||Published - 1995|
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