VARIABILITA INTRAINDIVIDUALE DEI LIVELLI BASALI DELLA CICLOSPORINA ED EFFICACIA DELLA IMMUNODEPRESSIONE

Translated title of the contribution: Intraindividual variability of cyclosporine blood levels and its effects on patient's immunosuppression

A. Elli, P. Palazzi, F. Nicosia, S. Zafiropulu, S. Tedeschi, F. Quarto Di Palo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We evaluated mean cyclosporine (CSA) level and its variation coefficient (CVC) in 100 non-immunized recipients of cadaver renal transplants over a five-year period. The mean intraindividual variability of CSA blood levels was 25.3% (min 5%, max 71%) with a median value of 27.7%. Patients were divided into two groups (Group A: CVC 28%) and both groups were compared for graft function and survival. Patients of Group A showed stability in renal function and only 10.5% of the grafts were lost for rejection. In patients of Group B plasma creatinine levels increased from 122 ± 3.8 to 179 ± 11.5 μM/l over the five-year period of the study (p <0.001); creatinine clearance decreased (p <0.05) and a greater graft loss (31.9%) was observed. In conclusion, an elevated intraindividual variability of CSA through blood levels was associated with increased risk of renal function deterioration and graft loss.

Original languageItalian
Pages (from-to)269-273
Number of pages5
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume12
Issue number4
Publication statusPublished - 1995

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Immunosuppression
Cyclosporine
Transplants
Kidney
Creatinine
Graft Survival
Cadaver

ASJC Scopus subject areas

  • Nephrology

Cite this

VARIABILITA INTRAINDIVIDUALE DEI LIVELLI BASALI DELLA CICLOSPORINA ED EFFICACIA DELLA IMMUNODEPRESSIONE. / Elli, A.; Palazzi, P.; Nicosia, F.; Zafiropulu, S.; Tedeschi, S.; Quarto Di Palo, F.

In: Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia, Vol. 12, No. 4, 1995, p. 269-273.

Research output: Contribution to journalArticle

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AU - Palazzi, P.

AU - Nicosia, F.

AU - Zafiropulu, S.

AU - Tedeschi, S.

AU - Quarto Di Palo, F.

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AB - We evaluated mean cyclosporine (CSA) level and its variation coefficient (CVC) in 100 non-immunized recipients of cadaver renal transplants over a five-year period. The mean intraindividual variability of CSA blood levels was 25.3% (min 5%, max 71%) with a median value of 27.7%. Patients were divided into two groups (Group A: CVC 28%) and both groups were compared for graft function and survival. Patients of Group A showed stability in renal function and only 10.5% of the grafts were lost for rejection. In patients of Group B plasma creatinine levels increased from 122 ± 3.8 to 179 ± 11.5 μM/l over the five-year period of the study (p <0.001); creatinine clearance decreased (p <0.05) and a greater graft loss (31.9%) was observed. In conclusion, an elevated intraindividual variability of CSA through blood levels was associated with increased risk of renal function deterioration and graft loss.

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