Intralesional (incision) biopsy for melanoma diagnosis: the rules and the exception to the rules

Elvira Moscarella, Giuseppe Argenziano, Claudia Moreno-Moreno, Simonetta Piana, Aimilios Lallas, Mara Lombardi, Caterina Longo, Gerardo Ferrara

Research output: Contribution to journalArticlepeer-review


Intralesional (incision) biopsy for melanoma diagnosis can be warranted for large lesions or for lesions whose in toto excision leads to cosmetic and/or functional impairment. However, this diagnostic approach carries a risk of underdiagnosis, if a clinicopathologic diagnostic approach is not implemented. As a rule, in large pigmented lesions from special body areas (scalp and acral skin), clinicodermoscopic differential diagnosis of melanoma includes non-melanocytic skin lesions, or traumatic skin changes, rather then nevi. The unique indication to incision biopsy for the differential diagnosis between nevus and melanoma is a relatively small nodular proliferation developing within a medium-large congenital nevus.

Original languageEnglish
JournalGiornale Italiano di Dermatologia e Venereologia
Publication statusE-pub ahead of print - Apr 20 2016


  • Journal Article


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