Intralymphatic spread is a common finding in cutaneous CD30+ lymphoproliferative disorders

Gerardo Ferrara, Luca Ena, Carlo Cota, Lorenzo Cerroni

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An intralymphatic variant of the cutaneous CD30+ lymphoproliferative disorders (cutaneous anaplastic large cell lymphoma [ALCL] and lymphomatoid papulosis [LyP]) has been described recently. We retrieved 60 cases of ALCL of the skin (primary cutaneous: 37; cases with concomitant involvement of 1 regional lymph node: 4; skin involvement from systemic disease: 4; cases with staging results unknown: 15) and 16 cases of LyP, to evaluate the presence of lymphatic vessel involvement by neoplastic cells. A D2-40 immunohistochemical staining was used to highlight lymphatic vessels. Lymphatic vessel involvement was found in 36 cases (60%) of ALCL (primary cutaneous: 24; concomitant: 3; secondary cutaneous: 4; staging unknown: 5), and in 6 cases (37.5%) of LyP. Follow-up data, available in 28 patients with ALCL and 11 with LyP, suggested that lymphatic vessel involvement had no negative prognostic implication. Our study demonstrates that cutaneous CD30+ lymphoproliferative disorders are frequently characterized by involvement of the lymphatic vessels. The intralymphatic variant of ALCL and LyP may be explained, at least in part, by a particular lymphotropism of the neoplastic cells of cutaneous CD30+ lymphoproliferative disorders.

Original languageEnglish
Pages (from-to)1511-1517
Number of pages7
JournalAmerican Journal of Surgical Pathology
Issue number11
Publication statusPublished - 2015


  • Cutaneous anaplastic large cell lymphoma
  • Cutaneous t-cell lymphoma
  • Intralymphatic cutaneous anaplastic large cell lymphoma
  • Intravascular nk/t-cell lymphoma
  • Lymphomatoid papulosis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery
  • Medicine(all)


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