Abstract
Objective - To investigate the time course of troponin-T release into the extracellular fluid of the myocardium and to distinguish between a rise in troponin-T due to implantation trauma and an increase due to cardiac arrest during coronary surgery. Design - Microdialysis probes were implanted in the heart of seven patients soon after sternotomy. Troponin-T was measured in the microdialysates and in peripheral blood from 3 h before to 24 h after heart arrest. Results - The troponin-T concentration in the microdialysates increased immediately after probe implantation and decreased to baseline within 70 min. This early peak is interpreted to reflect a local trauma. Three hours after cross-clamp release, a second peak of microdialysate troponin-T was recorded; 50 times higher than in serum. Eight to 24 h later a third peak occurred in five patients. Serum troponin-T was below the detection level at the beginning of the operation but increased linearly during the first 3 h of reperfusion and remained at that level thereafter. Conclusion - Microdialysis is a safe technique providing more information on myocardial metabolism during and after bypass surgery than can be obtained from peripheral blood. The release of troponin-T in response to cardiac arrest can be distinguished in time from the local tissue response to probe implantation.
| Original language | English |
|---|---|
| Pages (from-to) | 308-312 |
| Number of pages | 5 |
| Journal | Scandinavian Cardiovascular Journal |
| Volume | 36 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Ischemia
- Myocardium
- Postoperative surveillance
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Intramyocardial troponin-T monitoring with microdialysis in coronary artery bypass surgery. / Mantovani, Vittorio; Kennergren, Charles; Berglin, Eva; Moratti, Remigio; Lönnroth, Peter; Hamberger, Anders; Viganó, Mario.
In: Scandinavian Cardiovascular Journal, Vol. 36, No. 5, 2002, p. 308-312.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intramyocardial troponin-T monitoring with microdialysis in coronary artery bypass surgery
AU - Mantovani, Vittorio
AU - Kennergren, Charles
AU - Berglin, Eva
AU - Moratti, Remigio
AU - Lönnroth, Peter
AU - Hamberger, Anders
AU - Viganó, Mario
PY - 2002
Y1 - 2002
N2 - Objective - To investigate the time course of troponin-T release into the extracellular fluid of the myocardium and to distinguish between a rise in troponin-T due to implantation trauma and an increase due to cardiac arrest during coronary surgery. Design - Microdialysis probes were implanted in the heart of seven patients soon after sternotomy. Troponin-T was measured in the microdialysates and in peripheral blood from 3 h before to 24 h after heart arrest. Results - The troponin-T concentration in the microdialysates increased immediately after probe implantation and decreased to baseline within 70 min. This early peak is interpreted to reflect a local trauma. Three hours after cross-clamp release, a second peak of microdialysate troponin-T was recorded; 50 times higher than in serum. Eight to 24 h later a third peak occurred in five patients. Serum troponin-T was below the detection level at the beginning of the operation but increased linearly during the first 3 h of reperfusion and remained at that level thereafter. Conclusion - Microdialysis is a safe technique providing more information on myocardial metabolism during and after bypass surgery than can be obtained from peripheral blood. The release of troponin-T in response to cardiac arrest can be distinguished in time from the local tissue response to probe implantation.
AB - Objective - To investigate the time course of troponin-T release into the extracellular fluid of the myocardium and to distinguish between a rise in troponin-T due to implantation trauma and an increase due to cardiac arrest during coronary surgery. Design - Microdialysis probes were implanted in the heart of seven patients soon after sternotomy. Troponin-T was measured in the microdialysates and in peripheral blood from 3 h before to 24 h after heart arrest. Results - The troponin-T concentration in the microdialysates increased immediately after probe implantation and decreased to baseline within 70 min. This early peak is interpreted to reflect a local trauma. Three hours after cross-clamp release, a second peak of microdialysate troponin-T was recorded; 50 times higher than in serum. Eight to 24 h later a third peak occurred in five patients. Serum troponin-T was below the detection level at the beginning of the operation but increased linearly during the first 3 h of reperfusion and remained at that level thereafter. Conclusion - Microdialysis is a safe technique providing more information on myocardial metabolism during and after bypass surgery than can be obtained from peripheral blood. The release of troponin-T in response to cardiac arrest can be distinguished in time from the local tissue response to probe implantation.
KW - Ischemia
KW - Myocardium
KW - Postoperative surveillance
UR - http://www.scopus.com/inward/record.url?scp=0036433313&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036433313&partnerID=8YFLogxK
U2 - 10.1080/140174302320774537
DO - 10.1080/140174302320774537
M3 - Article
C2 - 12470400
AN - SCOPUS:0036433313
VL - 36
SP - 308
EP - 312
JO - Scandinavian Cardiovascular Journal
JF - Scandinavian Cardiovascular Journal
SN - 1401-7431
IS - 5
ER -