Intranasal buserelin versus surgery in the treatment of uterine leiomyomata: long-term follow-up

Luigi Fedele, Stefano Blanchi, Andrea Baglioni, Luisa Arcaini, Maurizio Marchini, Luca Bocciolone

Research output: Contribution to journalArticlepeer-review


Forty-two women with symptomatic uterine myomas, candidates for myomectomy or hysterectomy, were randomized to 6 months' treatment with buserelin 1200 μg/day intranasally (n = 22) or immediate surgery (n = 20). After buserelin treatment or operation the patients were followed for at least 12 months. Busereliin was well tolerated, the uterine volume fell from 465 ± 168 to 273 ± 88 cm3, and hemoglobin values normalized in all anemic patients. Rapid myoma regrowth was observed in all patients in the buserelin group after treatment withdrawal. Pregnancy occurred during follow-up in one of five buserelin-treated myomectomy candidates. Menorrhagia recurred in eight of 15 buserelin-treated hysterectomy candidates, and a hysterectomy was required but no transfusion was needed. Two women entered natural menopause and were considered cured. In the surgery group all operations were uneventful: three women conceived after myomectomy, whereas four of the patients that underwent hysterectomy required transfusions. Thus buserelin treatment appears to be indicated for infertile patients when surgery is contra-indicated or could cause adhesions, and for hysterectomy candidates in perimenopausal age and/or with secondary anemia.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number1
Publication statusPublished - Jan 4 1991

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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