Dexmedetomidina intranasale per sedazione procedurale

Translated title of the contribution: Intranasal dexmedetomidine for procedural sedation

Giorgio Cozzi, Giuliana Morabito, Giulia Caddeo, Stefania Norbedo, Natalia Maximova, Federico Poropat, Francesca Barbieri, Davide Zanon, Alessandra Maestro, Laura Travan, Stefano Furlan, Egidio Barbi

Research output: Contribution to journalArticlepeer-review


Sedation outside the operating theatre for diagnostic and therapeutic procedures in childre is more and more frequently performed. Most of the sedative drugs commonly used i this setting, such as midazolam, chloral hydrate and propofol, may induce respiratory depressio and apnoea. Dexmedetomidine is a high selective alpha2-Adrenergic receptor agonis that acts in the locus coeruleus and induces a natural state of non-rapid eye movemen sleep. Contrary to most of the other sedatives, it preserves respiratory drive. Moreover it neither causes respiratory depression nor influences the patency and tone of the airways Dexmedetomidine use in paediatrics has been extensively evaluated in clinical studie in the intensive care unit setting. Recently, substantial evidence has showed its efficac and safety via the intranasal route outside the intensive care setting. Dexmedetomidine ha only a minor analgesic effect, so its use is ideal for non-painful diagnostic radiological o instrumental procedures. The main adverse event reported with dexmedetomidine is a relativ haemodynamic variability, which only rarely needs a medical support. All these feature make dexmedetomidine use particularly interesting for non-painful procedures outsid the operating theatre. However, in Italy its use via the intranasal route is still off-label.

Translated title of the contributionIntranasal dexmedetomidine for procedural sedation
Original languageItalian
Pages (from-to)641-645
Number of pages5
JournalMedico e Bambino
Issue number10
Publication statusPublished - Dec 1 2016

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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