Intranasal glucagon as remedy for hypoglycemia. Studies in healthy subjects and type I diabetic patients

A. E. Pontiroli, A. Calderara, E. Pajetta, M. Alberetto, G. Pozza

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Intranasal glucagon can rise blood glucose levels in healthy subjects. The aims of this study were to 1) compare the hyperglycemic effects of intranasal and intramuscular glucagon in healthy subjects and type I (insulin-dependent) diabetes patients during euglycemic conditions and 2) test the efficacy of intranasal and intramuscular glucagon in counteracting hypoglycemic episodes in insulin-treated diabetic patients. Intranasal glucagon raised blood glucose levels in both healthy subjects and type I diabetic patients, the effect of intramuscular glucagon being similar to the first 30 min and higher thereafter. Intranasal glucagon was also quicker acting than oral glucose in healthy subjects. Intranasal glucagon raised blood glucose levels in patients with hypoglycemic episodes, although less effectively than intramuscular glucagon. These data indicate intranasal glucagon as a possible emergency remedy for self-medication in insulin-treated patients prone to hypoglycemic episodes.

Original languageEnglish
Pages (from-to)604-608
Number of pages5
JournalDiabetes Care
Volume12
Issue number9
Publication statusPublished - 1989

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Glucagon
Hypoglycemia
Healthy Volunteers
Hypoglycemic Agents
Blood Glucose
Insulin
Self Medication
Emergencies
Glucose

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Intranasal glucagon as remedy for hypoglycemia. Studies in healthy subjects and type I diabetic patients. / Pontiroli, A. E.; Calderara, A.; Pajetta, E.; Alberetto, M.; Pozza, G.

In: Diabetes Care, Vol. 12, No. 9, 1989, p. 604-608.

Research output: Contribution to journalArticle

Pontiroli, AE, Calderara, A, Pajetta, E, Alberetto, M & Pozza, G 1989, 'Intranasal glucagon as remedy for hypoglycemia. Studies in healthy subjects and type I diabetic patients', Diabetes Care, vol. 12, no. 9, pp. 604-608.
Pontiroli, A. E. ; Calderara, A. ; Pajetta, E. ; Alberetto, M. ; Pozza, G. / Intranasal glucagon as remedy for hypoglycemia. Studies in healthy subjects and type I diabetic patients. In: Diabetes Care. 1989 ; Vol. 12, No. 9. pp. 604-608.
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