Intranigral kainic acid is evidence that nigral non-dopaminergic neurones control posture

G. Di Chiara, M. Olianas, M. Del Fiacco, P. F. Spano, A. Tagliamonte

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

THE substantia nigra has a key role in the control of posture and in the coordination of movements. This function is currently attributed to the dopaminergic neurones ascending from the pars compacta of the nigra to the neostriatum. In fact unilateral lesion of this pathway by intranigral injection of 6-hydroxydopamine (6OH-DA) produces a dramatic asymmetry consisting of a tendency of the animal to turn towards the side of the lesion (ipsilateral turning)1. But, unilateral electrolytic lesions of the substantia nigra, while similarly effective to 6OH-DA in destroying dopaminergic neurones, result in turning towards the intact side (contralateral turning)2,4. This has been taken to indicate the existence of non-dopaminergic neurones arising from or traversing the nigra, which control turning behaviour in a manner opposite to the nigro-neostriatal dopaminergic neurones2,4. We report here that unilateral intranigral injection of kainic acid5,6 produces a sustained contralateral turning independent from dopaminergic nigro-striatal function. Since kainic acid spares axons but produces neuronal loss in the pars reticulata of the nigra, our results indicate the existence of non-dopaminergic neurones originating in the pars reticulata which control turning behaviour and posture in a manner opposite to the nigrostriatal dopamine (DA) neurones.

Original languageEnglish
Pages (from-to)743-745
Number of pages3
JournalNature
Volume268
Issue number5622
DOIs
Publication statusPublished - 1977

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Kainic Acid
Dopaminergic Neurons
Substantia Nigra
Posture
Behavior Control
Neurons
Dopamine
Neostriatum
Corpus Striatum
Injections
Oxidopamine
Axons
Pars Reticulata

ASJC Scopus subject areas

  • General

Cite this

Di Chiara, G., Olianas, M., Del Fiacco, M., Spano, P. F., & Tagliamonte, A. (1977). Intranigral kainic acid is evidence that nigral non-dopaminergic neurones control posture. Nature, 268(5622), 743-745. https://doi.org/10.1038/268743a0

Intranigral kainic acid is evidence that nigral non-dopaminergic neurones control posture. / Di Chiara, G.; Olianas, M.; Del Fiacco, M.; Spano, P. F.; Tagliamonte, A.

In: Nature, Vol. 268, No. 5622, 1977, p. 743-745.

Research output: Contribution to journalArticle

Di Chiara, G, Olianas, M, Del Fiacco, M, Spano, PF & Tagliamonte, A 1977, 'Intranigral kainic acid is evidence that nigral non-dopaminergic neurones control posture', Nature, vol. 268, no. 5622, pp. 743-745. https://doi.org/10.1038/268743a0
Di Chiara G, Olianas M, Del Fiacco M, Spano PF, Tagliamonte A. Intranigral kainic acid is evidence that nigral non-dopaminergic neurones control posture. Nature. 1977;268(5622):743-745. https://doi.org/10.1038/268743a0
Di Chiara, G. ; Olianas, M. ; Del Fiacco, M. ; Spano, P. F. ; Tagliamonte, A. / Intranigral kainic acid is evidence that nigral non-dopaminergic neurones control posture. In: Nature. 1977 ; Vol. 268, No. 5622. pp. 743-745.
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