Variabilità intra-osservatore e inter-osservatore nel calcolo del coefficiente di diffusione apparente (ADC) con risonanza magnetica pesata in diffusione (RM-DW) nei tumori della mammella

Translated title of the contribution: Intraobserver and interobserver variability in the calculation of apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (DW-MRI) of breast tumours

G. Petralia, L. Bonello, P. Summers, L. Preda, A. Malasevschi, S. Raimondi, R. Di Filippi, M. Locatelli, G. Curigliano, G. Renne, M. Bellomi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: This study evaluated intraobserver and interobserver variability in the measurement of apparent diffusion coefficient (ADC) values in breast carcinomas. Materials and methods: Twenty-eight patients with solid breast lesions >10 mm underwent conventional contrast-enhanced magnetic resonance imaging (MRI) and diffusion-weighted MRI (DW-MRI). Two observers (expert and trainee) segmented the lesion from the surrounding breast tissue on DW images with high b-value (1,000 s/mm 2). This analysis was repeated by the expert reader after 6 months. Volumes were analysed to obtain mean, median and standard deviation (SD) of the ADC values. Interobserver and intraobserver variation was analysed using the Bland-Altman graph. Results: All lesions were breast carcinomas, with a mean ADC value of 1.07 × 10 -3 mm 2/s. The mean of the differences was 0.012 × 10 -3 mm 2/s, corresponding to an intraobserver variability of 1.1% (limits of agreement: -5%/+8%). The mean interobserver difference was 0.022 × 10 -3 mm 2/s, corresponding to an interobserver variability of 2% (limits of agreement: -9%/+14%). Conclusions: We found a low intraobserver and interobserver variability in calculating ADC in breast carcinomas, which supports its potential use in routine clinical practice.

Translated title of the contributionIntraobserver and interobserver variability in the calculation of apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (DW-MRI) of breast tumours
Original languageItalian
Pages (from-to)466-476
Number of pages11
JournalRadiologia Medica
Volume116
Issue number3
DOIs
Publication statusPublished - Apr 2011

ASJC Scopus subject areas

  • Medicine(all)
  • Radiology Nuclear Medicine and imaging

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