Intraocular lens surface properties investigated with nanometer scale resolution using atomic force microscopy

Marco Lombardo, Giuseppe Lombardo, Giovanni Carbone, Maria P. De Santo, Sebastiano Serrao, Riccardo Barberi

Research output: Chapter in Book/Report/Conference proceedingChapter


The posterior capsular opacification (PCO) represents the most significant cause ofvisual impairment after cataract surgery. During the last decade, a great deal of work hasbeen conducted to analyze which intraocular lens (IOL) property could primarilyinfluence the rate and severity of PCO. It was found that the geometrical design of IOLaffects the rate of PCO and it has been proven that a sharp IOL posterior optic edgeimproves the prevention of PCO. On the other hand, the surface properties of the IOLbiomaterial also appeared to play a relevant role in preventing PCO.In this work we investigate, with nanometer scale resolution, the physical propertiesof the surface for the IOL biomaterials currently in use in the clinical environment: polymethyl-methacrylate (PMMA), silicone, hydrophilic acrylic and hydrophobic acrylic. AnAtomic Force Microscope was used both to measure the topography and adhesiveness ofIOLs' optic surface. Analysis of IOLs was performed in liquid environment. The topography measurements of the IOLs' optic were performed using anAutoprobe CP (Veeco, Sunnyvale, CA) operated in the contact mode and V-shapedcantilevers with a 0.01 Newton/meter (N/m) nominal elastic constant. The topography ofIOLs' surface revealed different features strongly correlated with both the lensbiomaterial and the processes used to manufacture the IOLs. The root mean square (RMS)roughness of the IOL optic surface was significantly different between lenses of variousmaterials (P

Original languageEnglish
Title of host publicationCataracts: Causes, Symptoms, and Surgery
PublisherNova Science Publishers, Inc.
Number of pages16
ISBN (Print)9781616689551
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Medicine(all)


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