Intraocular Pressure-Lowering Effects of Latanoprost Monotherapy versus Latanoprost or Pilocarpine in Combination with Timolol: A Randomized, Observer-Masked Multicenter Study in Patients with Open-Angle Glaucoma

Massimo G. Bucci, Gian Luca Manni, Mauro Schiavonc, Rosario Brancato, Roberto Carassa, Luigi Cardia, Francesco Cantatore, Renato Frezzotti, Rossella Ciappetta, Paolo Frezzotti, Dario De Marco, Roberto Cian, Ugo Menchini, Ettore Ferrari, Mario Miglior, Pasquale Troiano, Giovanni Rama, Alfonso Zampini, Albino Rapizzi, Enrico DaniottiAlfredo Reibaldi, Maurizio Uva, Giovanni Prosdocimo, Mario Zingirian, Giovanni Calabria

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Purpose: To compare intraocular pressure (IOP) after adding either latanoprost or pilocarpine to timolol treatment or switching to latanoprost monotherapy in glaucomatous eyes in which IOP was inadequately controlled with timolol. Methods: This 6-month randomized study comprised 148 patients with primary open-angle or pseudoexfoliation glaucoma, which was inadequately controlled with topical beta-adrenergic antagonists. After a 2- to 4-week run-in period with timolol 0.5% twice daily, patients were assigned in randomized fashion to three study groups: one group received add-on therapy of latanoprost 0.005% once daily, the second group received add-on therapy of pilocarpine 2% three times daily, and the third group switched to latanoprost 0.005% once daily. Mean diurnal IOP was measured at baseline and after 3 and 6 months of treatment. Results: At 6 months, 128 patients had completed the study. Diurnal IOP was significantly reduced from baseline in all groups. Adding latanoprost to timolol treatment reduced diurnal IOP by 6.1 ± 0.3 mmHg (-28%), adding pilocarpine to timolol treatment reduced diurnal IOP by 4.2 ± 0.3 mmHg (-19%), and switching from timolol to latanoprost monotherapy reduced diurnal IOP by 5.5 ± 0.3 mmHg (-25%). Conclusion: A significantly greater reduction in diurnal IOP was achieved after addition of latanoprost than after addition of pilocarpine in patients in whom IOP was not adequately controlled with timolol alone. Further, the results of this study indicate that a switch to latanoprost monotherapy can be attempted before combination treatment is initiated.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalJournal of Glaucoma
Volume8
Issue number1
Publication statusPublished - Feb 1999

Fingerprint

latanoprost
Timolol
Pilocarpine
Open Angle Glaucoma
Intraocular Pressure
Multicenter Studies
Therapeutics
Adrenergic beta-Antagonists

Keywords

  • Additivity
  • Glaucoma
  • Intraocular pressure
  • Latanoprost
  • Monotherapy
  • Pilocarpine
  • Timolol

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Intraocular Pressure-Lowering Effects of Latanoprost Monotherapy versus Latanoprost or Pilocarpine in Combination with Timolol : A Randomized, Observer-Masked Multicenter Study in Patients with Open-Angle Glaucoma. / Bucci, Massimo G.; Manni, Gian Luca; Schiavonc, Mauro; Brancato, Rosario; Carassa, Roberto; Cardia, Luigi; Cantatore, Francesco; Frezzotti, Renato; Ciappetta, Rossella; Frezzotti, Paolo; De Marco, Dario; Cian, Roberto; Menchini, Ugo; Ferrari, Ettore; Miglior, Mario; Troiano, Pasquale; Rama, Giovanni; Zampini, Alfonso; Rapizzi, Albino; Daniotti, Enrico; Reibaldi, Alfredo; Uva, Maurizio; Prosdocimo, Giovanni; Zingirian, Mario; Calabria, Giovanni.

In: Journal of Glaucoma, Vol. 8, No. 1, 02.1999, p. 24-30.

Research output: Contribution to journalArticle

Bucci, MG, Manni, GL, Schiavonc, M, Brancato, R, Carassa, R, Cardia, L, Cantatore, F, Frezzotti, R, Ciappetta, R, Frezzotti, P, De Marco, D, Cian, R, Menchini, U, Ferrari, E, Miglior, M, Troiano, P, Rama, G, Zampini, A, Rapizzi, A, Daniotti, E, Reibaldi, A, Uva, M, Prosdocimo, G, Zingirian, M & Calabria, G 1999, 'Intraocular Pressure-Lowering Effects of Latanoprost Monotherapy versus Latanoprost or Pilocarpine in Combination with Timolol: A Randomized, Observer-Masked Multicenter Study in Patients with Open-Angle Glaucoma', Journal of Glaucoma, vol. 8, no. 1, pp. 24-30.
Bucci, Massimo G. ; Manni, Gian Luca ; Schiavonc, Mauro ; Brancato, Rosario ; Carassa, Roberto ; Cardia, Luigi ; Cantatore, Francesco ; Frezzotti, Renato ; Ciappetta, Rossella ; Frezzotti, Paolo ; De Marco, Dario ; Cian, Roberto ; Menchini, Ugo ; Ferrari, Ettore ; Miglior, Mario ; Troiano, Pasquale ; Rama, Giovanni ; Zampini, Alfonso ; Rapizzi, Albino ; Daniotti, Enrico ; Reibaldi, Alfredo ; Uva, Maurizio ; Prosdocimo, Giovanni ; Zingirian, Mario ; Calabria, Giovanni. / Intraocular Pressure-Lowering Effects of Latanoprost Monotherapy versus Latanoprost or Pilocarpine in Combination with Timolol : A Randomized, Observer-Masked Multicenter Study in Patients with Open-Angle Glaucoma. In: Journal of Glaucoma. 1999 ; Vol. 8, No. 1. pp. 24-30.
@article{c07c1918c33c4b08adde3f1d6d730725,
title = "Intraocular Pressure-Lowering Effects of Latanoprost Monotherapy versus Latanoprost or Pilocarpine in Combination with Timolol: A Randomized, Observer-Masked Multicenter Study in Patients with Open-Angle Glaucoma",
abstract = "Purpose: To compare intraocular pressure (IOP) after adding either latanoprost or pilocarpine to timolol treatment or switching to latanoprost monotherapy in glaucomatous eyes in which IOP was inadequately controlled with timolol. Methods: This 6-month randomized study comprised 148 patients with primary open-angle or pseudoexfoliation glaucoma, which was inadequately controlled with topical beta-adrenergic antagonists. After a 2- to 4-week run-in period with timolol 0.5{\%} twice daily, patients were assigned in randomized fashion to three study groups: one group received add-on therapy of latanoprost 0.005{\%} once daily, the second group received add-on therapy of pilocarpine 2{\%} three times daily, and the third group switched to latanoprost 0.005{\%} once daily. Mean diurnal IOP was measured at baseline and after 3 and 6 months of treatment. Results: At 6 months, 128 patients had completed the study. Diurnal IOP was significantly reduced from baseline in all groups. Adding latanoprost to timolol treatment reduced diurnal IOP by 6.1 ± 0.3 mmHg (-28{\%}), adding pilocarpine to timolol treatment reduced diurnal IOP by 4.2 ± 0.3 mmHg (-19{\%}), and switching from timolol to latanoprost monotherapy reduced diurnal IOP by 5.5 ± 0.3 mmHg (-25{\%}). Conclusion: A significantly greater reduction in diurnal IOP was achieved after addition of latanoprost than after addition of pilocarpine in patients in whom IOP was not adequately controlled with timolol alone. Further, the results of this study indicate that a switch to latanoprost monotherapy can be attempted before combination treatment is initiated.",
keywords = "Additivity, Glaucoma, Intraocular pressure, Latanoprost, Monotherapy, Pilocarpine, Timolol",
author = "Bucci, {Massimo G.} and Manni, {Gian Luca} and Mauro Schiavonc and Rosario Brancato and Roberto Carassa and Luigi Cardia and Francesco Cantatore and Renato Frezzotti and Rossella Ciappetta and Paolo Frezzotti and {De Marco}, Dario and Roberto Cian and Ugo Menchini and Ettore Ferrari and Mario Miglior and Pasquale Troiano and Giovanni Rama and Alfonso Zampini and Albino Rapizzi and Enrico Daniotti and Alfredo Reibaldi and Maurizio Uva and Giovanni Prosdocimo and Mario Zingirian and Giovanni Calabria",
year = "1999",
month = "2",
language = "English",
volume = "8",
pages = "24--30",
journal = "Journal of Glaucoma",
issn = "1057-0829",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Intraocular Pressure-Lowering Effects of Latanoprost Monotherapy versus Latanoprost or Pilocarpine in Combination with Timolol

T2 - A Randomized, Observer-Masked Multicenter Study in Patients with Open-Angle Glaucoma

AU - Bucci, Massimo G.

AU - Manni, Gian Luca

AU - Schiavonc, Mauro

AU - Brancato, Rosario

AU - Carassa, Roberto

AU - Cardia, Luigi

AU - Cantatore, Francesco

AU - Frezzotti, Renato

AU - Ciappetta, Rossella

AU - Frezzotti, Paolo

AU - De Marco, Dario

AU - Cian, Roberto

AU - Menchini, Ugo

AU - Ferrari, Ettore

AU - Miglior, Mario

AU - Troiano, Pasquale

AU - Rama, Giovanni

AU - Zampini, Alfonso

AU - Rapizzi, Albino

AU - Daniotti, Enrico

AU - Reibaldi, Alfredo

AU - Uva, Maurizio

AU - Prosdocimo, Giovanni

AU - Zingirian, Mario

AU - Calabria, Giovanni

PY - 1999/2

Y1 - 1999/2

N2 - Purpose: To compare intraocular pressure (IOP) after adding either latanoprost or pilocarpine to timolol treatment or switching to latanoprost monotherapy in glaucomatous eyes in which IOP was inadequately controlled with timolol. Methods: This 6-month randomized study comprised 148 patients with primary open-angle or pseudoexfoliation glaucoma, which was inadequately controlled with topical beta-adrenergic antagonists. After a 2- to 4-week run-in period with timolol 0.5% twice daily, patients were assigned in randomized fashion to three study groups: one group received add-on therapy of latanoprost 0.005% once daily, the second group received add-on therapy of pilocarpine 2% three times daily, and the third group switched to latanoprost 0.005% once daily. Mean diurnal IOP was measured at baseline and after 3 and 6 months of treatment. Results: At 6 months, 128 patients had completed the study. Diurnal IOP was significantly reduced from baseline in all groups. Adding latanoprost to timolol treatment reduced diurnal IOP by 6.1 ± 0.3 mmHg (-28%), adding pilocarpine to timolol treatment reduced diurnal IOP by 4.2 ± 0.3 mmHg (-19%), and switching from timolol to latanoprost monotherapy reduced diurnal IOP by 5.5 ± 0.3 mmHg (-25%). Conclusion: A significantly greater reduction in diurnal IOP was achieved after addition of latanoprost than after addition of pilocarpine in patients in whom IOP was not adequately controlled with timolol alone. Further, the results of this study indicate that a switch to latanoprost monotherapy can be attempted before combination treatment is initiated.

AB - Purpose: To compare intraocular pressure (IOP) after adding either latanoprost or pilocarpine to timolol treatment or switching to latanoprost monotherapy in glaucomatous eyes in which IOP was inadequately controlled with timolol. Methods: This 6-month randomized study comprised 148 patients with primary open-angle or pseudoexfoliation glaucoma, which was inadequately controlled with topical beta-adrenergic antagonists. After a 2- to 4-week run-in period with timolol 0.5% twice daily, patients were assigned in randomized fashion to three study groups: one group received add-on therapy of latanoprost 0.005% once daily, the second group received add-on therapy of pilocarpine 2% three times daily, and the third group switched to latanoprost 0.005% once daily. Mean diurnal IOP was measured at baseline and after 3 and 6 months of treatment. Results: At 6 months, 128 patients had completed the study. Diurnal IOP was significantly reduced from baseline in all groups. Adding latanoprost to timolol treatment reduced diurnal IOP by 6.1 ± 0.3 mmHg (-28%), adding pilocarpine to timolol treatment reduced diurnal IOP by 4.2 ± 0.3 mmHg (-19%), and switching from timolol to latanoprost monotherapy reduced diurnal IOP by 5.5 ± 0.3 mmHg (-25%). Conclusion: A significantly greater reduction in diurnal IOP was achieved after addition of latanoprost than after addition of pilocarpine in patients in whom IOP was not adequately controlled with timolol alone. Further, the results of this study indicate that a switch to latanoprost monotherapy can be attempted before combination treatment is initiated.

KW - Additivity

KW - Glaucoma

KW - Intraocular pressure

KW - Latanoprost

KW - Monotherapy

KW - Pilocarpine

KW - Timolol

UR - http://www.scopus.com/inward/record.url?scp=0033070534&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033070534&partnerID=8YFLogxK

M3 - Article

C2 - 10084271

AN - SCOPUS:0033070534

VL - 8

SP - 24

EP - 30

JO - Journal of Glaucoma

JF - Journal of Glaucoma

SN - 1057-0829

IS - 1

ER -