Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus

Paolo Vinciguerra, Elena Albè, Silvia Trazza, Theo Seiler, Daniel Epstein

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Objectives: To report intraoperative and 24-month refractive, topographic, tomographic, and aberrometric outcomes after corneal collagen cross-linking in progressive advanced keratoconus. Methods: Prospective, nonrandomized single-center clinical study involving 28 eyes. Main outcome measures included uncorrected and best spectacle-corrected visual acuities, sphere and cylinder refraction, topography, tomography, aberrometry, and endothelial cell count evaluated at baseline and follow-up at 1, 3, 6, 12, and 24 months after treatment. Topography was also recorded intraoperatively. Results: Two years after treatment, mean baseline uncorrected and best spectacle-corrected visual acuities improved significantly (P=.048 and 0 (piston), Z2 (defocus), and Z7 (III coma) decreased significantly (P≤.046). Mean 12-month baseline pupil center pachymetry and total corneal volume decreased significantly (P=.045). Endothelial cell counts did not change significantly (P=.13). Conclusions: Two years postoperatively, corneal collagen cross-linking appears to be effective in improving uncorrected and best spectacle-corrected visual acuities in eyes with progressive keratoconus by significantly reducing corneal average pupillary power, apical keratometry, and total corneal wavefront aberrations.

Original languageEnglish
Pages (from-to)1258-1265
Number of pages8
JournalArchives of Ophthalmology
Volume127
Issue number10
DOIs
Publication statusPublished - Oct 2009

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Keratoconus
Visual Acuity
Collagen
Corneal Wavefront Aberration
Aberrometry
Endothelial Cells
Cell Count
Corneal Pachymetry
Pupil
Coma
Tomography
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus. / Vinciguerra, Paolo; Albè, Elena; Trazza, Silvia; Seiler, Theo; Epstein, Daniel.

In: Archives of Ophthalmology, Vol. 127, No. 10, 10.2009, p. 1258-1265.

Research output: Contribution to journalArticle

Vinciguerra, Paolo ; Albè, Elena ; Trazza, Silvia ; Seiler, Theo ; Epstein, Daniel. / Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus. In: Archives of Ophthalmology. 2009 ; Vol. 127, No. 10. pp. 1258-1265.
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