Intraoperative beta- detecting probe for radio-guided surgery of brain tumors

G. Baroni, F. Bellini, V. Bocci, F. Collamati, M. Cremonesi, E. De Lucia, R. Faccini, P. Ferroli, S. Fiore, F. Fioroni, C. M. Grana, E. Grassi, M. Iori, M. Marafini, I. Mattei, S. Morganti, G. Paganelli, V. Patera, A. Pepe, L. PiersantiL. Recchia, A. Russomando, A. Sarti, A. Sciubba, M. Schiariti, E. Solfaroli Camillocci, A. Versari, C. Voena

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The innovation of the radio-guided surgery exploiting β- emitters is the higher tumor-to-non-tumor ratio (TNR) allowing both a smaller radiopharmaceutical absorbed dose to detect cancerous remnants and the possibility of extending the technique also to cases with a large uptake of surrounding healthy organs, as for brain tumors. Our first study cases are meningiomas, since an appropriate β- emitting drug is already available (90Y-DOTATOC), but the goal is to apply this technique to gliomas. We verified the uptake of the radiotracer in 8/10 patients affected by meningiomas with TNR ≥ 10 and in 9/12 patients with a TNR ≥ 4 in case of gliomas. We developed prototypes of an intraoperative probe detecting β- radiation. The core of the probe is a millimetric scintillator made of para-terphenyl due to its high light yield and low density. Tests in laboratory showed that with a radiotracer activity on the tumor of 5 kBq/ml and a TNR of 10 a 0.1 ml cancerous residual can be detected in 1s. That corresponds to administer to the patient 1 MBq/kg of radiopharmaceutical, which is a dose comparable to those administered for diagnostic use. Finally we estimated with a detailed simulation the exposure of the surgeon resulted in ∼0.1 Sv/h to the whole body and ∼1 Sv/h to the hands, well below the corresponding values for established RGS with gamma radiation.

Original languageEnglish
Title of host publication2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781479960972
DOIs
Publication statusPublished - Mar 10 2016
EventIEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 - Seattle, United States
Duration: Nov 8 2014Nov 15 2014

Other

OtherIEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
CountryUnited States
CitySeattle
Period11/8/1411/15/14

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Intraoperative beta- detecting probe for radio-guided surgery of brain tumors'. Together they form a unique fingerprint.

  • Cite this

    Baroni, G., Bellini, F., Bocci, V., Collamati, F., Cremonesi, M., De Lucia, E., Faccini, R., Ferroli, P., Fiore, S., Fioroni, F., Grana, C. M., Grassi, E., Iori, M., Marafini, M., Mattei, I., Morganti, S., Paganelli, G., Patera, V., Pepe, A., ... Voena, C. (2016). Intraoperative beta- detecting probe for radio-guided surgery of brain tumors. In 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 [7430882] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2014.7430882