Abstract
The innovation of the radio-guided surgery exploiting β- emitters is the higher tumor-to-non-tumor ratio (TNR) allowing both a smaller radiopharmaceutical absorbed dose to detect cancerous remnants and the possibility of extending the technique also to cases with a large uptake of surrounding healthy organs, as for brain tumors. Our first study cases are meningiomas, since an appropriate β- emitting drug is already available (90Y-DOTATOC), but the goal is to apply this technique to gliomas. We verified the uptake of the radiotracer in 8/10 patients affected by meningiomas with TNR ≥ 10 and in 9/12 patients with a TNR ≥ 4 in case of gliomas. We developed prototypes of an intraoperative probe detecting β- radiation. The core of the probe is a millimetric scintillator made of para-terphenyl due to its high light yield and low density. Tests in laboratory showed that with a radiotracer activity on the tumor of 5 kBq/ml and a TNR of 10 a 0.1 ml cancerous residual can be detected in 1s. That corresponds to administer to the patient 1 MBq/kg of radiopharmaceutical, which is a dose comparable to those administered for diagnostic use. Finally we estimated with a detailed simulation the exposure of the surgeon resulted in ∼0.1 Sv/h to the whole body and ∼1 Sv/h to the hands, well below the corresponding values for established RGS with gamma radiation.
| Original language | English |
|---|---|
| Title of host publication | 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| ISBN (Print) | 9781479960972 |
| DOIs | |
| Publication status | Published - Mar 10 2016 |
| Event | IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 - Seattle, United States Duration: Nov 8 2014 → Nov 15 2014 |
Other
| Other | IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 |
|---|---|
| Country | United States |
| City | Seattle |
| Period | 11/8/14 → 11/15/14 |
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ASJC Scopus subject areas
- Nuclear and High Energy Physics
- Radiology Nuclear Medicine and imaging
Cite this
Intraoperative beta- detecting probe for radio-guided surgery of brain tumors. / Baroni, G.; Bellini, F.; Bocci, V.; Collamati, F.; Cremonesi, M.; De Lucia, E.; Faccini, R.; Ferroli, P.; Fiore, S.; Fioroni, F.; Grana, C. M.; Grassi, E.; Iori, M.; Marafini, M.; Mattei, I.; Morganti, S.; Paganelli, G.; Patera, V.; Pepe, A.; Piersanti, L.; Recchia, L.; Russomando, A.; Sarti, A.; Sciubba, A.; Schiariti, M.; Camillocci, E. Solfaroli; Versari, A.; Voena, C.
2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014. Institute of Electrical and Electronics Engineers Inc., 2016. 7430882.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Intraoperative beta- detecting probe for radio-guided surgery of brain tumors
AU - Baroni, G.
AU - Bellini, F.
AU - Bocci, V.
AU - Collamati, F.
AU - Cremonesi, M.
AU - De Lucia, E.
AU - Faccini, R.
AU - Ferroli, P.
AU - Fiore, S.
AU - Fioroni, F.
AU - Grana, C. M.
AU - Grassi, E.
AU - Iori, M.
AU - Marafini, M.
AU - Mattei, I.
AU - Morganti, S.
AU - Paganelli, G.
AU - Patera, V.
AU - Pepe, A.
AU - Piersanti, L.
AU - Recchia, L.
AU - Russomando, A.
AU - Sarti, A.
AU - Sciubba, A.
AU - Schiariti, M.
AU - Camillocci, E. Solfaroli
AU - Versari, A.
AU - Voena, C.
PY - 2016/3/10
Y1 - 2016/3/10
N2 - The innovation of the radio-guided surgery exploiting β- emitters is the higher tumor-to-non-tumor ratio (TNR) allowing both a smaller radiopharmaceutical absorbed dose to detect cancerous remnants and the possibility of extending the technique also to cases with a large uptake of surrounding healthy organs, as for brain tumors. Our first study cases are meningiomas, since an appropriate β- emitting drug is already available (90Y-DOTATOC), but the goal is to apply this technique to gliomas. We verified the uptake of the radiotracer in 8/10 patients affected by meningiomas with TNR ≥ 10 and in 9/12 patients with a TNR ≥ 4 in case of gliomas. We developed prototypes of an intraoperative probe detecting β- radiation. The core of the probe is a millimetric scintillator made of para-terphenyl due to its high light yield and low density. Tests in laboratory showed that with a radiotracer activity on the tumor of 5 kBq/ml and a TNR of 10 a 0.1 ml cancerous residual can be detected in 1s. That corresponds to administer to the patient 1 MBq/kg of radiopharmaceutical, which is a dose comparable to those administered for diagnostic use. Finally we estimated with a detailed simulation the exposure of the surgeon resulted in ∼0.1 Sv/h to the whole body and ∼1 Sv/h to the hands, well below the corresponding values for established RGS with gamma radiation.
AB - The innovation of the radio-guided surgery exploiting β- emitters is the higher tumor-to-non-tumor ratio (TNR) allowing both a smaller radiopharmaceutical absorbed dose to detect cancerous remnants and the possibility of extending the technique also to cases with a large uptake of surrounding healthy organs, as for brain tumors. Our first study cases are meningiomas, since an appropriate β- emitting drug is already available (90Y-DOTATOC), but the goal is to apply this technique to gliomas. We verified the uptake of the radiotracer in 8/10 patients affected by meningiomas with TNR ≥ 10 and in 9/12 patients with a TNR ≥ 4 in case of gliomas. We developed prototypes of an intraoperative probe detecting β- radiation. The core of the probe is a millimetric scintillator made of para-terphenyl due to its high light yield and low density. Tests in laboratory showed that with a radiotracer activity on the tumor of 5 kBq/ml and a TNR of 10 a 0.1 ml cancerous residual can be detected in 1s. That corresponds to administer to the patient 1 MBq/kg of radiopharmaceutical, which is a dose comparable to those administered for diagnostic use. Finally we estimated with a detailed simulation the exposure of the surgeon resulted in ∼0.1 Sv/h to the whole body and ∼1 Sv/h to the hands, well below the corresponding values for established RGS with gamma radiation.
UR - http://www.scopus.com/inward/record.url?scp=84965082645&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84965082645&partnerID=8YFLogxK
U2 - 10.1109/NSSMIC.2014.7430882
DO - 10.1109/NSSMIC.2014.7430882
M3 - Conference contribution
AN - SCOPUS:84965082645
SN - 9781479960972
BT - 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
PB - Institute of Electrical and Electronics Engineers Inc.
ER -