Intraoperative beta- detecting probe for radio-guided surgery of brain tumors

Guido Baroni, Fabio Bellini, Valerio Bocci, Francesco Collamati, Marta Cremonesi, Erika De Lucia, Riccardo Faccini, Paolo Ferroli, S. Fiore, Federica Fioroni, Chiara Maria Grana, Elisa Grassi, Mauro Iori, Michela Marafini, Ilaria Mattei, Silvio Morganti, Giovanni Paganelli, Vincenzo Patera, Alessandra Pepe, Luca PiersantiLuigi Recchia, Andrea Russomando, A. Sarti, A. Sciubba, Marco Paolo Schiariti, E. Solfaroli Camillocci, Annibale Versari, Cecilia Voena

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The innovation of the radio-guided surgery exploiting β- emitters is the higher tumor-to-non-tumor ratio (TNR) allowing both a smaller radiopharmaceutical absorbed dose to detect cancerous remnants and the possibility of extending the technique also to cases with a large uptake of surrounding healthy organs, as for brain tumors. Our first study cases are meningiomas, since an appropriate β- emitting drug is already available (90Y-DOTATOC), but the goal is to apply this technique to gliomas. We verified the uptake of the radiotracer in 8/10 patients affected by meningiomas with TNR ≥ 10 and in 9/12 patients with a TNR ≥ 4 in case of gliomas. We developed prototypes of an intraoperative probe detecting β- radiation. The core of the probe is a millimetric scintillator made of para-terphenyl due to its high light yield and low density. Tests in laboratory showed that with a radiotracer activity on the tumor of 5 kBq/ml and a TNR of 10 a 0.1 ml cancerous residual can be detected in 1s. That corresponds to administer to the patient 1 MBq/kg of radiopharmaceutical, which is a dose comparable to those administered for diagnostic use. Finally we estimated with a detailed simulation the exposure of the surgeon resulted in ∼0.1 Sv/h to the whole body and ∼1 Sv/h to the hands, well below the corresponding values for established RGS with gamma radiation.

Original languageEnglish
Title of host publication2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
DOIs
Publication statusPublished - Mar 10 2016

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Intraoperative beta- detecting probe for radio-guided surgery of brain tumors'. Together they form a unique fingerprint.

Cite this