Intraoperative microrecordings in the posterior hypothalamus of anaesthetized humans with aggressive behaviour

Roberto Cordella, F. Carella, A. Franzini, C. Marras, F. Villani, G. Messina, G. Tringali, G. Broggi

Research output: Contribution to journalArticlepeer-review

Abstract

Two patients with uncontrollable aggressive behaviour underwent the placement of stimulating leads in the posterior hypothalamus (pHyp). One patient had also multifocal refractory epilepsy. Microrecordings were obtained in both patients during surgery under general anaesthesia. Firing rate, interspike intervals and oscillatory discharge patterns were analysed in 14 neurons. A mean discharge rate of 19 Hz, and oscillatory activity at 7-8 Hz were recorded in the first patient with aggressiveness and epilepsy. In the second patient the mean firing rate was 10 Hz, with evidence of both tonic and random firing patterns. Previous studies in patients with cluster headache showed that a discharge rate around 20 Hz and lack of a specific rhythmic pattern were the most consistent characteristics of neuronal discharge in this area. Our present findings therefore would suggest that the pattern of discharge of neurons in the pHyp should be evaluated with reference to the presence of concurrent pathology.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalNeurological Sciences
Volume31
Issue number2
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Aggressive behaviour
  • Epilepsy
  • Neuronal discharge pattern
  • Posterior hypothalamus

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

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