Radioterapia intraoperatoria nei tumori maligni avanzati estesi all’orecchio medio: Valutazione da uno studio retrospettivo

Translated title of the contribution: Intraoperative radiation therapy as adjuvant treatment in locally advanced stage tumours involving the middle ear: A hypothesis-generating retrospective study

Giovanni Cristalli, Giuseppe Mercante, L. Marucci, Antonella Soriani, S. Telera, G. Spriano

Research output: Contribution to journalArticle

Abstract

The objective of this study was to evaluate the safety, effectiveness and functional outcomes of intraoperative radiotherapy (IORT) followed by intensity-modulated radiation therapy (IMRT) in locally advanced stage tumours involving the middle ear. Data on 13 consecutive patients treated for malignant tumor of external auditory canal involving the middle ear were retrospectively reviewed. Median follow-up was 33 months (range 6-133). Five (38%) patients were stage III and 8 (62%) were Stage IV according to the University of Pittsburgh staging system. Lateral temporal bone resection (LTBR) was performed in all cases. LTBR was associated with parotidectomy in 5 (38%) cases, and with neck dissection and parotidectomy in 6 (46%) cases. No patients had gross residual tumour. Surgical treatment was followed by IORT (12 Gy) and IMRT (50 Gy). Adjuvant chemotherapy was used in 4 (30%) cases. Preoperative and postoperative audiometric tests were performed to assess hearing loss. 5-year local-control (LC), 5-year distant-metastasis (DM), 5-year disease-free-survival (DFS) and 5-year overall-survival (OS) were calculated with Kaplan-Meyer method. Significant changes in bone conduction were reported after treatment. Partial flap necrosis was the only early complication observed in three (23%) cases, while meningeal fistula was seen in one (7.6%) case as a late complication. The 5-year LC-rate was 68%. The 5-year DM-rate was 90%. The 5-year DFS-rate was 61%. The 5-year OS-rate was 69%. IORT followed by IMRT for the treatment of advanced external auditory canal and middle ear tumours seems to be safe. No intraoperative death was reported. IORT may reduce the postoperative irradiation of remnant tissue obtaining the same full dose on the tumour bed. No complications of the residual external ear were observed. Detriment of neurosensory hearing may be expected. Future studies are required to confirm the benefit of this procedure in the ear.

Original languageItalian
Pages (from-to)85-90
Number of pages6
JournalActa Otorhinolaryngologica Italica
Volume36
Issue number2
DOIs
Publication statusPublished - Apr 1 2016

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Middle Ear
Radiotherapy
Retrospective Studies
Intensity-Modulated Radiotherapy
Ear Canal
Temporal Bone
Neoplasms
Disease-Free Survival
Survival Rate
Bone Conduction
Neoplasm Metastasis
External Ear
Therapeutics
Neck Dissection
Residual Neoplasm
Adjuvant Chemotherapy
Hearing Loss
Hearing
Fistula
Ear

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Radioterapia intraoperatoria nei tumori maligni avanzati estesi all’orecchio medio : Valutazione da uno studio retrospettivo. / Cristalli, Giovanni; Mercante, Giuseppe; Marucci, L.; Soriani, Antonella; Telera, S.; Spriano, G.

In: Acta Otorhinolaryngologica Italica, Vol. 36, No. 2, 01.04.2016, p. 85-90.

Research output: Contribution to journalArticle

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