Intraoperative radiation therapy for breast cancer: Technical notes

Umberto Veronesi, Giovanna Gatti, Alberto Luini, Mattia Intra, Roberto Orecchia, Patrick Borgen, Michael Zelefsky, Beryl McCormick, Virgilio Sacchini

Research output: Contribution to journalArticlepeer-review


Interest in intraoperative radiation therapy (IORT) for breast cancer is increasing as the possible benefits of this technique for the patient become apparent. The rationale for the use of this segmental radiation therapy in place of whole-breast irradiation is based on the finding that approximately 85% of breast relapses are confined to the same quadrant of the breast as the primary tumor. Phase I and II trials have demonstrated no increase in postsurgical complication rates following the use of single-dose IORT in localized breast cancers. Longer follow-up is needed to assess the cosmetic outcome. Clinical trials to evaluate the effectiveness of IORT in the treatment of breast cancer are currently under way at the European Institute of Oncology (EIO) at the University of Milan, Italy, and at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York. Here we report the two different techniques in use in these trials.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalBreast Journal
Issue number2
Publication statusPublished - Mar 2003


  • Breast cancer
  • Intraoperative radiation therapy
  • Surgical technique

ASJC Scopus subject areas

  • Internal Medicine
  • Oncology


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