Intraoperative radiotherapy during breast conserving surgery

A study on 1,822 cases treated with electrons

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Intraoperative radiotherapy with electrons (ELIOT) after conservative surgery for breast carcinoma was introduced at the IEO in 1999 as a research programme. The results on 1,822 patients treated from January 2000 to December 2008 are reported. Women with unicentric primary breast carcinoma of less than 2.5 cm in the largest diameter were assessed by imaging. All patients were treated with breast-conserving surgery (quadrantectomy). ELIOT was delivered by two mobile linear accelerators immediately after breast resection with a single dose of 21 Gy. Local side effects of ELIOT were mainly liponecrosis (4.2%) and fibrosis (1.8%). After a mean follow-up of 36.1 months, 42 women (2.3%) developed a local recurrence, 24 (1.3%) a new primary ipsilateral carcinomas and 26 (1.4%) distant metastases as first event. Forty-six women died (2.5%), 28 for breast carcinoma and 18 for other causes. Five- and ten-year survivals were, respectively, 97.4 and 89.7%. ELIOT appears a promising feature in early breast cancer treated with breast conserving surgery, reducing the exposure of normal tissues to radiations and shortening the radiation course from 6 weeks to one single session.

Original languageEnglish
Pages (from-to)141-151
Number of pages11
JournalBreast Cancer Research and Treatment
Volume124
Issue number1
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Segmental Mastectomy
Radiotherapy
Electrons
Breast Neoplasms
Radiation
Particle Accelerators
Breast
Fibrosis
Neoplasm Metastasis
Carcinoma
Recurrence
Survival
Research

Keywords

  • Breast cancer
  • Conserving surgery
  • Intraoperative radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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title = "Intraoperative radiotherapy during breast conserving surgery: A study on 1,822 cases treated with electrons",
abstract = "Intraoperative radiotherapy with electrons (ELIOT) after conservative surgery for breast carcinoma was introduced at the IEO in 1999 as a research programme. The results on 1,822 patients treated from January 2000 to December 2008 are reported. Women with unicentric primary breast carcinoma of less than 2.5 cm in the largest diameter were assessed by imaging. All patients were treated with breast-conserving surgery (quadrantectomy). ELIOT was delivered by two mobile linear accelerators immediately after breast resection with a single dose of 21 Gy. Local side effects of ELIOT were mainly liponecrosis (4.2{\%}) and fibrosis (1.8{\%}). After a mean follow-up of 36.1 months, 42 women (2.3{\%}) developed a local recurrence, 24 (1.3{\%}) a new primary ipsilateral carcinomas and 26 (1.4{\%}) distant metastases as first event. Forty-six women died (2.5{\%}), 28 for breast carcinoma and 18 for other causes. Five- and ten-year survivals were, respectively, 97.4 and 89.7{\%}. ELIOT appears a promising feature in early breast cancer treated with breast conserving surgery, reducing the exposure of normal tissues to radiations and shortening the radiation course from 6 weeks to one single session.",
keywords = "Breast cancer, Conserving surgery, Intraoperative radiotherapy",
author = "Umberto Veronesi and Roberto Orecchia and Alberto Luini and Viviana Galimberti and Stefano Zurrida and Mattia Intra and Paolo Veronesi and Paolo Arnone and Leonardi, {Maria Cristina} and Mario Ciocca and Roberta Lazzari and Pietro Caldarella and Nicole Rotmensz and Claudia Sangalli and Daniele Sances and Patrick Maisonneuve",
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T2 - A study on 1,822 cases treated with electrons

AU - Veronesi, Umberto

AU - Orecchia, Roberto

AU - Luini, Alberto

AU - Galimberti, Viviana

AU - Zurrida, Stefano

AU - Intra, Mattia

AU - Veronesi, Paolo

AU - Arnone, Paolo

AU - Leonardi, Maria Cristina

AU - Ciocca, Mario

AU - Lazzari, Roberta

AU - Caldarella, Pietro

AU - Rotmensz, Nicole

AU - Sangalli, Claudia

AU - Sances, Daniele

AU - Maisonneuve, Patrick

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