Intraoperative radiotherapy during breast conserving surgery in patients previously treated with radiotherapy for Hodgkin's disease

Mattia Intra, Maria Cristina Leonardi, Giovanna Gatti, Anna Rita Vento, Mario Ciocca, Paolo Veronesi, Guillermo Bassani, Gabriela Rosali Dos Santos, Julia Rodriguez, Alberto Luini, Roberto Orecchia, Umberto Veronesi

Research output: Contribution to journalArticle


Aims and background: Women who have received radiotherapy for Hodgkin's disease have an increased risk of developing breast cancer. Breast-conserving surgery followed by breast irradiation is generally considered to be contraindicated in such patients owing to the high cumulative radiation dose to the breast. Mastectomy is therefore recommended as the preferred treatment option in these women. Methods: We report 3 patients affected by breast cancer who had previously been treated with mantle radiation for Hodgkin's disease and on whom breast-conserving surgery and full-dose intraoperative radiotherapy with electrons (ELIOT) were performed. Results: A total dose of 17 Gy (prescribed at 100% isodose) in one case and 21 Gy (at the 90% isodose) in two cases was delivered directly to the mammary gland without acute complications and with good cosmetic results. Conclusions: In women previously irradiated for Hodgkin's disease, ELIOT could avoid repeat irradiation of the whole breast, thereby permitting conservative surgical treatment.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
Issue number1
Publication statusPublished - Jan 2004



  • Breast cancer
  • Breast-conserving surgery
  • Hodgkin's disease
  • Intraoperative radiotherapy
  • IORT
  • Lymphoma

ASJC Scopus subject areas

  • Cancer Research

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