Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): A randomised controlled equivalence trial

Umberto Veronesi; Roberto Orecchia; Patrick Maisonneuve; Giuseppe Viale; Nicole Rotmensz; Claudia Sangalli; Alberto Luini; Paolo Veronesi; Viviana Galimberti; Stefano Zurrida; Maria Cristina Leonardi; Roberta Lazzari; Federica Cattani; Oreste Gentilini; Mattia Intra; Pietro Caldarella; Bettina Ballardini

doi:10.1016/S1470-2045(13)70497-2

Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): A randomised controlled equivalence trial

Umberto Veronesi, Roberto Orecchia, Patrick Maisonneuve, Giuseppe Viale, Nicole Rotmensz, Claudia Sangalli, Alberto Luini, Paolo Veronesi, Viviana Galimberti, Stefano Zurrida, Maria Cristina Leonardi, Roberta Lazzari, Federica Cattani, Oreste Gentilini, Mattia Intra, Pietro Caldarella, Bettina Ballardini

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Intraoperative radiotherapy with electrons allows the substitution of conventional postoperative whole breast irradiation with one session of radiotherapy with the same equivalent dose during surgery. However, its ability to control for recurrence of local disease required confirmation in a randomised controlled trial. Methods: This study was done at the European Institute of Oncology (Milan, Italy). Women aged 48-75 years with early breast cancer, a maximum tumour diameter of up to 2·5 cm, and suitable for breast-conserving surgery were randomly assigned in a 1:1 ratio (using a random permuted block design, stratified for clinical tumour size [

Original language	English
Pages (from-to)	1269-1277
Number of pages	9
Journal	The Lancet Oncology
Volume	14
Issue number	13
DOIs	https://doi.org/10.1016/S1470-2045(13)70497-2
Publication status	Published - Dec 2013

ASJC Scopus subject areas

Oncology

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Veronesi, U., Orecchia, R., Maisonneuve, P., Viale, G., Rotmensz, N., Sangalli, C., Luini, A., Veronesi, P., Galimberti, V., Zurrida, S., Leonardi, M. C., Lazzari, R., Cattani, F., Gentilini, O., Intra, M., Caldarella, P., & Ballardini, B. (2013). Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): A randomised controlled equivalence trial. The Lancet Oncology, 14(13), 1269-1277. https://doi.org/10.1016/S1470-2045(13)70497-2

Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT) : A randomised controlled equivalence trial. / Veronesi, Umberto; Orecchia, Roberto ; Maisonneuve, Patrick ; Viale, Giuseppe; Rotmensz, Nicole; Sangalli, Claudia ; Luini, Alberto ; Veronesi, Paolo ; Galimberti, Viviana; Zurrida, Stefano; Leonardi, Maria Cristina ; Lazzari, Roberta ; Cattani, Federica ; Gentilini, Oreste ; Intra, Mattia ; Caldarella, Pietro ; Ballardini, Bettina.

In: The Lancet Oncology, Vol. 14, No. 13, 12.2013, p. 1269-1277.

Research output: Contribution to journal › Article › peer-review

Veronesi, U, Orecchia, R , Maisonneuve, P , Viale, G, Rotmensz, N, Sangalli, C , Luini, A , Veronesi, P , Galimberti, V, Zurrida, S, Leonardi, MC , Lazzari, R , Cattani, F , Gentilini, O , Intra, M , Caldarella, P & Ballardini, B 2013, 'Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): A randomised controlled equivalence trial', The Lancet Oncology, vol. 14, no. 13, pp. 1269-1277. https://doi.org/10.1016/S1470-2045(13)70497-2

Veronesi, Umberto ; Orecchia, Roberto ; Maisonneuve, Patrick ; Viale, Giuseppe ; Rotmensz, Nicole ; Sangalli, Claudia ; Luini, Alberto ; Veronesi, Paolo ; Galimberti, Viviana ; Zurrida, Stefano ; Leonardi, Maria Cristina ; Lazzari, Roberta ; Cattani, Federica ; Gentilini, Oreste ; Intra, Mattia ; Caldarella, Pietro ; Ballardini, Bettina. / Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT) : A randomised controlled equivalence trial. In: The Lancet Oncology. 2013 ; Vol. 14, No. 13. pp. 1269-1277.

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