Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): A randomised controlled equivalence trial

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Abstract

Background: Intraoperative radiotherapy with electrons allows the substitution of conventional postoperative whole breast irradiation with one session of radiotherapy with the same equivalent dose during surgery. However, its ability to control for recurrence of local disease required confirmation in a randomised controlled trial. Methods: This study was done at the European Institute of Oncology (Milan, Italy). Women aged 48-75 years with early breast cancer, a maximum tumour diameter of up to 2·5 cm, and suitable for breast-conserving surgery were randomly assigned in a 1:1 ratio (using a random permuted block design, stratified for clinical tumour size [

Original languageEnglish
Pages (from-to)1269-1277
Number of pages9
JournalThe Lancet Oncology
Volume14
Issue number13
DOIs
Publication statusPublished - Dec 2013

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Radiotherapy
Randomized Controlled Trials
Breast Neoplasms
Segmental Mastectomy
Italy
Neoplasms
Breast
Electrons
Recurrence

ASJC Scopus subject areas

  • Oncology

Cite this

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abstract = "Background: Intraoperative radiotherapy with electrons allows the substitution of conventional postoperative whole breast irradiation with one session of radiotherapy with the same equivalent dose during surgery. However, its ability to control for recurrence of local disease required confirmation in a randomised controlled trial. Methods: This study was done at the European Institute of Oncology (Milan, Italy). Women aged 48-75 years with early breast cancer, a maximum tumour diameter of up to 2·5 cm, and suitable for breast-conserving surgery were randomly assigned in a 1:1 ratio (using a random permuted block design, stratified for clinical tumour size [",
author = "Umberto Veronesi and Roberto Orecchia and Patrick Maisonneuve and Giuseppe Viale and Nicole Rotmensz and Claudia Sangalli and Alberto Luini and Paolo Veronesi and Viviana Galimberti and Stefano Zurrida and Leonardi, {Maria Cristina} and Roberta Lazzari and Federica Cattani and Oreste Gentilini and Mattia Intra and Pietro Caldarella and Bettina Ballardini",
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TY - JOUR

T1 - Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT)

T2 - A randomised controlled equivalence trial

AU - Veronesi, Umberto

AU - Orecchia, Roberto

AU - Maisonneuve, Patrick

AU - Viale, Giuseppe

AU - Rotmensz, Nicole

AU - Sangalli, Claudia

AU - Luini, Alberto

AU - Veronesi, Paolo

AU - Galimberti, Viviana

AU - Zurrida, Stefano

AU - Leonardi, Maria Cristina

AU - Lazzari, Roberta

AU - Cattani, Federica

AU - Gentilini, Oreste

AU - Intra, Mattia

AU - Caldarella, Pietro

AU - Ballardini, Bettina

PY - 2013/12

Y1 - 2013/12

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