Intraperitoneal administration of interferon β in ovarian cancer patients

A. Rambaldi, M. Introna, F. Colotta, S. Landolfo, N. Colombo, C. Mangioni, A. Mantovani

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Eight patients with advanced ovarian carcinomas resistant to conventional chemotherapy were injected with interferon (IFN) β (3 x 106 U) intraperitoneally twice a week. Seven subjects had ascites. Side effects included abdominal pain, fever, and constipation, but no hematologic toxicity was observed. Growth of solid tumor lesions was unaffected by IFNβ, with the possible exception of one patient who had stable disease. IFNβ intraperitoneally inhibited completely the formation of ascites in four of seven patients with effusions. Natural killer (NK) cell activity was measured in peripheral blood and tumor-associated lymphocytes (PBL and TAL). Using stringent criteria that included repeated assessment of baseline activity, a clear cut increase in NK cytotoxicity of TAL was detected in two of six subjects from whom TAL could be purified. Augmentation of NK activity was restricted to the peritoneal compartment with no effect on PBL. Studies on biologic response modifiers encompassing an analysis of events taking place at sites directly involved by neoplasia may provide an opportunity for generating information on the in situ regulation of tumor-associated host defense mechanisms in humans.

Original languageEnglish
Pages (from-to)294-301
Number of pages8
JournalCancer
Volume56
Issue number2
DOIs
Publication statusPublished - 1985

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Ovarian Neoplasms
Interferons
Ascites
Neoplasms
Population Growth
Constipation
Natural Killer Cells
Abdominal Pain
Fever
Lymphocytes
Carcinoma
Drug Therapy
Growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Intraperitoneal administration of interferon β in ovarian cancer patients. / Rambaldi, A.; Introna, M.; Colotta, F.; Landolfo, S.; Colombo, N.; Mangioni, C.; Mantovani, A.

In: Cancer, Vol. 56, No. 2, 1985, p. 294-301.

Research output: Contribution to journalArticle

Rambaldi, A. ; Introna, M. ; Colotta, F. ; Landolfo, S. ; Colombo, N. ; Mangioni, C. ; Mantovani, A. / Intraperitoneal administration of interferon β in ovarian cancer patients. In: Cancer. 1985 ; Vol. 56, No. 2. pp. 294-301.
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