Abstract
From August 1985 to November 1989 we conducted a trial of intraperitoneal (IP) carboplatin including a dose-escalation design in 25 women with advanced gynecologic malignancies. All had extensive prior therapy with cisplatin (median cumulative dose, 525 mg/m 2). Carboplatin was administered IP in 2 L of 1.5% dextrose with a 4-hour dwell time every 4 weeks for six cyles at a starting dose of 200 mg/m 2. Patients with reduced creatinine clearance (30 to 60 cc/min) were escalated more slowly than those with high (> 66 cc/min) clearance. Thrombocytopenia was dose-limiting and often more severe in patients with compromised renal function; there was no local drug toxicity. The median time of follow-up is 25 months. Complete responses (CRs) were documented in six of 23 assessable patients (26%) by repeat laparotomy, and an additional 11 patients (48%) had no disease evident by noninvasive restaging. Five of the CRs and six of the patients with no clinically evident disease have relapsed from 3 to 40 months after therapy. Six patients (26%) are alive and free of disease 8 to 47 (median, 20) months after therapy. IP carboplatin is effective against relapsed ovarian cancer, even after prior cisplatin therapy.
Original language | English |
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Pages (from-to) | 1335-1341 |
Number of pages | 7 |
Journal | Journal of Clinical Oncology |
Volume | 8 |
Issue number | 8 |
Publication status | Published - 1990 |
ASJC Scopus subject areas
- Cancer Research
- Oncology