TY - JOUR
T1 - Intraperitoneal chemotherapy in advanced epithelial ovarian cancer
T2 - A survey
AU - Grosso, Giuseppe
AU - Rossetti, Diego
AU - Coccolini, Federico
AU - Bogani, Giorgio
AU - Ansaloni, Luca
AU - Frigerio, Luigi
PY - 2014
Y1 - 2014
N2 - Introduction: Intraperitoneal chemotherapy preceded by cytoreductive surgery should be the standard of care in the treatment of advanced epithelial ovarian cancer. This combination has been extensively examined in both the clinical and preclinical settings with favourable oncologic outcomes. Unfortunately, despite the existence of these evidence-based data, this management strategy remains underutilised. Materials and methods: We review and discuss the role of intraperitoneal chemotherapy with particular emphasis about the pharmacokinetics and pharmacodynamics aspects, the mode of administration, the reported side effects, the compliance of the patients and the clinical ongoing studies. Conclusions: Further studies investigating the pharmacokinetics and pharmacodynamics aspect of IP route may help to reduce toxicity pending more effective treatments.
AB - Introduction: Intraperitoneal chemotherapy preceded by cytoreductive surgery should be the standard of care in the treatment of advanced epithelial ovarian cancer. This combination has been extensively examined in both the clinical and preclinical settings with favourable oncologic outcomes. Unfortunately, despite the existence of these evidence-based data, this management strategy remains underutilised. Materials and methods: We review and discuss the role of intraperitoneal chemotherapy with particular emphasis about the pharmacokinetics and pharmacodynamics aspects, the mode of administration, the reported side effects, the compliance of the patients and the clinical ongoing studies. Conclusions: Further studies investigating the pharmacokinetics and pharmacodynamics aspect of IP route may help to reduce toxicity pending more effective treatments.
KW - Advanced ovarian cancer
KW - Cytoreductive surgery
KW - HIPEC
KW - Intraperitoneal chemotherapy
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U2 - 10.1007/s00404-014-3252-2
DO - 10.1007/s00404-014-3252-2
M3 - Article
C2 - 24845970
AN - SCOPUS:84905923105
VL - 290
SP - 425
EP - 434
JO - Archives of Gynecology
JF - Archives of Gynecology
SN - 0170-9925
IS - 3
ER -