TY - JOUR
T1 - Intraperitoneal chemotherapy in patients pretreated for ovarian cancer matched with patients treated with parenteral chemotherapy
AU - Nicoletto, Maria Ornella
AU - Casarin, Alessandra
AU - Baldoni, Alessandra
AU - Rulli, Eliana
AU - Tasca, Giulia
AU - Baretta, Zora
AU - Artioli, Grazia
AU - Lombardi, Giuseppe
AU - Cappetta, Alessandro
AU - Floriani, Irene
AU - Randon, Giovanni
AU - Valpione, Sara
AU - Litta, Piero
AU - Conte, Pierfranco
AU - Mocellin, Simone
AU - Aliberti, Camillo
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Background: Our aim was to analyze the impact of intraperitoneal chemotherapy (IPC), administered with direct peritoneal puncture, on the survival of patients with pretreated ovarian cancer in a real-life setting. Patients and Methods: This was a retrospective study comparing patients with advanced ovarian cancer treated with IPC (N=33) and patients treated with standard intravenous (i.v.) chemotherapy matching cases for known prognostic factors (age, platinum sensitivity, histological subgroup and grade). Data were then analyzed for survival with nested Cox multivariate regression. Results: The case matching resulted in two homogeneous cohorts by age, platinum sensitivity, resistance to therapy and histology. When analyzed by hazard ratio (HR), the number of previous treatments and IPC vs. i.v. therapy were significant (HR=1.97 for i.v. and HR=1.90 for each incremental previous treatment line, multivariate p
AB - Background: Our aim was to analyze the impact of intraperitoneal chemotherapy (IPC), administered with direct peritoneal puncture, on the survival of patients with pretreated ovarian cancer in a real-life setting. Patients and Methods: This was a retrospective study comparing patients with advanced ovarian cancer treated with IPC (N=33) and patients treated with standard intravenous (i.v.) chemotherapy matching cases for known prognostic factors (age, platinum sensitivity, histological subgroup and grade). Data were then analyzed for survival with nested Cox multivariate regression. Results: The case matching resulted in two homogeneous cohorts by age, platinum sensitivity, resistance to therapy and histology. When analyzed by hazard ratio (HR), the number of previous treatments and IPC vs. i.v. therapy were significant (HR=1.97 for i.v. and HR=1.90 for each incremental previous treatment line, multivariate p
KW - Intraperitoneal treatment
KW - Parenteral chemotherapy
KW - Pretreated ovarian cancer
M3 - Articolo
VL - 36
SP - 6541
EP - 6546
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 12
ER -