Intraperitoneal hyperthermic chemotherapy in gastric cancer: Rationale for a new approach

Federico Bozzetti, Maurizio Vaglini, Marcello Deraco

Research output: Contribution to journalArticlepeer-review

Abstract

There is preliminary evidence from experience in the treatment of various abdominal malignancies that intraperitoneal chemotherapy alone or combined with hyperthermia may attain a role in the therapeutic strategy. This paper considers the rationale for such an approach, as well as its current results and potential indications in patients with gastric cancer. The literature is critically reviewed, with special emphasis on specific topics such as patterns of tumor spread, mechanisms of local recurrence, the rationale for intraperitoneal chemotherapy and intraperitoneal hyperthermic chemotherapy, toxicity, and results from non-controlled as well as randomized clinical trials in patients with gastric cancer. There is some evidence that intraperitoneal hyperthermic chemotherapy has a favorable effect on clinical outcome in patients with limited peritoneal carcinomatosis or malignant ascitis and in those at risk of future peritoneal spread, such as patients with pT3-pT4 cancers or with positive cytology of the peritoneal fluid. Hyperthermic chemotherapy should be considered a promising approach in limited or impending peritoneal carcinomatosis, and should be included in the multidisciplinary approach to the treatment of locally advanced gastric cancer.

Original languageEnglish
Pages (from-to)483-488
Number of pages6
JournalTumori
Volume84
Issue number4
Publication statusPublished - Jul 1998

Keywords

  • Gastric cancer
  • Intraperitoneal hyperthermic chemotherapy
  • Locoregional chemotherapy
  • Malignant ascitis

ASJC Scopus subject areas

  • Cancer Research

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