Intraperitoneal insulin absorption after long-term intraperitoneal insulin therapy

Marina Scavini, Angela Pincelli, Giovanna Petrella, Gabriella Galimberti, Philip G. Zager, Michiela Torri, Guido Pozza

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

OBJECTIVE - To evaluate insulin absorption through the peritoneal membrane after long-term intraperitoneal insulin therapy using an implanted programmable device. RESEARCH DESIGN AND METHODS - Seven insulin-dependent diabetes mellitus (IDDM) patients implanted with a programmable pump were studied after 3 and 30 months of intraperitoneal insulin therapy. A 20-min square wave infusion of 15 IU of insulin was administered in the peritoneal space, and plasma glucose and plasma free insulin levels were monitored for 180 min. Hypoglycemia was prevented by intravenous glucose infusion. RESULTS - After 30 months of intraperitoneal insulin therapy, plasma free insulin profiles following the administration of insulin in the peritoneal space were similar to those observed at the beginning of this mode of therapy. CONCLUSIONS - In IDDM patients, intraperitoneal insulin absorption does not change after long-term intraperitoneal insulin therapy using an implanted device.

Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalDiabetes Care
Volume18
Issue number1
Publication statusPublished - Jan 1995

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Insulin
Therapeutics
Type 1 Diabetes Mellitus
Peritoneal Absorption
Glucose
Equipment and Supplies
Hypoglycemia
Intravenous Infusions
Research Design
Membranes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Scavini, M., Pincelli, A., Petrella, G., Galimberti, G., Zager, P. G., Torri, M., & Pozza, G. (1995). Intraperitoneal insulin absorption after long-term intraperitoneal insulin therapy. Diabetes Care, 18(1), 56-59.

Intraperitoneal insulin absorption after long-term intraperitoneal insulin therapy. / Scavini, Marina; Pincelli, Angela; Petrella, Giovanna; Galimberti, Gabriella; Zager, Philip G.; Torri, Michiela; Pozza, Guido.

In: Diabetes Care, Vol. 18, No. 1, 01.1995, p. 56-59.

Research output: Contribution to journalArticle

Scavini, M, Pincelli, A, Petrella, G, Galimberti, G, Zager, PG, Torri, M & Pozza, G 1995, 'Intraperitoneal insulin absorption after long-term intraperitoneal insulin therapy', Diabetes Care, vol. 18, no. 1, pp. 56-59.
Scavini M, Pincelli A, Petrella G, Galimberti G, Zager PG, Torri M et al. Intraperitoneal insulin absorption after long-term intraperitoneal insulin therapy. Diabetes Care. 1995 Jan;18(1):56-59.
Scavini, Marina ; Pincelli, Angela ; Petrella, Giovanna ; Galimberti, Gabriella ; Zager, Philip G. ; Torri, Michiela ; Pozza, Guido. / Intraperitoneal insulin absorption after long-term intraperitoneal insulin therapy. In: Diabetes Care. 1995 ; Vol. 18, No. 1. pp. 56-59.
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