INTERFERON-GAMMA PAR VOIE INTRAPERITONEALE. UN COMPLEMENT EFFICACE DE LA CHIMIOTHERAPIE DES CANCERS DE L'OVAIRE. A PROPOS D'UNE ETUDE EUROPEENNE DE 108 PATIENTES

Translated title of the contribution: Intraperitoneal interferon-gamma. An effective complementary treatment to chemotherapy in ovarien cancer. A European study of 108 cases

E. Pujade-Lauraine, J. P. Guastella, N. Colombo, E. Francois, P. Fumoleau, A. Monnier, M. A. Nooy, L. Mignot, R. Bugat, C. M D Oliviera, M. Mousseau, G. Netter, F. Maloisel, M. Brandely

Research output: Contribution to journalArticle

Abstract

One hundred and eight patients with residual epithelial ovarian cancer at second laparotomy, after first line plastine-based chemotherapy were treated with intraperitoneal rHU-interferon-gamma at a dose of 20 x 10 6 U/m2, twice a week for 3-4 months. 86% of the patients had residual macroscopic tumors and 33% bulky tumors (> 2 cm). From the 99 evaluable patients, 62 had an evaluative third laparotomy and nine additional patients a laparotomy. Complete pathologic and global response rates to interferon-gamma were 23 and 32% respectively. Age and tumor size were independently correlated with treatment response. Patients (n = 41) under the age of 60 with a tumor size less than 2 cm had a complete and global response rate of 42 and 54% respectively. Interferon-gamma was equally effective in chemo-resistant and chemosensitive tumors. Median duration of response was 21 months and median survival of responder patients was 86% at 2 years. In multivariate analysis, response to interferon-gamma was the most prominent prognostic factor of this population of patients with residual ovarian cancer.

Translated title of the contributionIntraperitoneal interferon-gamma. An effective complementary treatment to chemotherapy in ovarien cancer. A European study of 108 cases
Original languageFrench
Pages (from-to)163-170
Number of pages8
JournalBulletin du Cancer
Volume80
Issue number2
Publication statusPublished - 1993

Keywords

  • Interferon
  • Interferon-gamma
  • Intraperitoneal
  • Ovarian cancer
  • Second line therapy

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Pujade-Lauraine, E., Guastella, J. P., Colombo, N., Francois, E., Fumoleau, P., Monnier, A., Nooy, M. A., Mignot, L., Bugat, R., Oliviera, C. M. D., Mousseau, M., Netter, G., Maloisel, F., & Brandely, M. (1993). INTERFERON-GAMMA PAR VOIE INTRAPERITONEALE. UN COMPLEMENT EFFICACE DE LA CHIMIOTHERAPIE DES CANCERS DE L'OVAIRE. A PROPOS D'UNE ETUDE EUROPEENNE DE 108 PATIENTES. Bulletin du Cancer, 80(2), 163-170.