Intraperitoneal mitoxantrone: A feasibility and pharmacokinetic study

D. Civalleri, M. O. Vannozzi, F. DeCian, G. Lunardi, M. Steinweg, I. Pastrone, M. Viale, M. Esposito

Research output: Contribution to journalArticlepeer-review

Abstract

Fractionated doses have been advocated to prevent chemoperitonitis after intraperitoneal infusion of mitoxantrone. Patients with peritoneal carcinomatosis of various origin underwent surgery, including intestinal resections, with minimal residual disease. Peritoneal mitoxantrone in 1000 ml/m 2 saline was planned on the first post-operative day in groups of four patients (5 mg/m 2 for 3 and 5 days, 7.5 mg/m 2 for 3 and 4 days, 10 mg/m 2 for 2-4 days, if possible). Due to dose-limiting myelosuppression, only one and three patients received the 7.5-mg 4-day and 10-mg 3-day regimens, respectively. A total of 20 patients were consequently treated. Neither major complications nor severe pain were observed. Pharmacokinetics were completed on the 1st day in five 5-mg and five 10-mg patients, on the 5th day in three 5-mg patients, and on the 3rd day in one 10-mg patient. On the 1st day, mean peritoneal peak concentrations of mitoxantrone resulted 1.45 ± 0.56 (range 0.48-1.9) and 1.9 ± 0.85 (range 1.27-3.13) μg/ml in the 5-mg and 10-mg patients, respectively. Mean dialysate/plasma exposure (AUC) ratio was 115. Even in patients with sutures, early post-operative fractionated intraperitoneal mitoxantrone appears feasible and safe, with a high local advantage, for up to 5 days of treatment and a maximum tolerated total dose of 20-25 mg/m 2.

Original languageEnglish
Pages (from-to)172-179
Number of pages8
JournalEuropean Journal of Surgical Oncology
Volume28
Issue number2
DOIs
Publication statusPublished - Mar 2002

Keywords

  • Mitoxantrone
  • Parenteral infusions
  • Peritoneal neoplasms
  • Pharmacokinetics

ASJC Scopus subject areas

  • Oncology
  • Surgery

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