TY - JOUR
T1 - Intrapulmonary drug administration in neonatal and paediatric critical care
T2 - A comprehensive review
AU - De Luca, D.
AU - Cogo, P.
AU - Zecca, E.
AU - Piastra, M.
AU - Pietrini, D.
AU - Tridente, A.
AU - Conti, G.
AU - Carnielli, V. P.
PY - 2011/3/1
Y1 - 2011/3/1
N2 - Administration of drugs directly into the respiratory tree first was proposed a long time ago. Surfactant is the paradigmatic example of such therapies. Many other drugs have been used in the same way and further compounds are under investigation for this aim. In the last two decades, despite the wide number of drugs available for direct lung administration in critical care patients, few controlled data exist regarding their use in neonates and infants. This review will focus on drugs clinically available in a critical care setting for neonates and infants, including bronchodilators, pulmonary vasodilators, anti-inflammatory agents, mucolytics, resuscitative anti-infective agents, surfactants and other drugs. We provide an evidence-based comprehensive review of drugs available for intratracheal administration in paediatric and neonatal critical care and we examine possible advantages and risks for each proposed indication. Copyright
AB - Administration of drugs directly into the respiratory tree first was proposed a long time ago. Surfactant is the paradigmatic example of such therapies. Many other drugs have been used in the same way and further compounds are under investigation for this aim. In the last two decades, despite the wide number of drugs available for direct lung administration in critical care patients, few controlled data exist regarding their use in neonates and infants. This review will focus on drugs clinically available in a critical care setting for neonates and infants, including bronchodilators, pulmonary vasodilators, anti-inflammatory agents, mucolytics, resuscitative anti-infective agents, surfactants and other drugs. We provide an evidence-based comprehensive review of drugs available for intratracheal administration in paediatric and neonatal critical care and we examine possible advantages and risks for each proposed indication. Copyright
KW - Critical care
KW - Infant
KW - Inhaled drug
UR - http://www.scopus.com/inward/record.url?scp=79953680731&partnerID=8YFLogxK
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U2 - 10.1183/09031936.00024910
DO - 10.1183/09031936.00024910
M3 - Article
C2 - 21357925
AN - SCOPUS:79953680731
VL - 37
SP - 678
EP - 689
JO - European Journal of Respiratory Diseases
JF - European Journal of Respiratory Diseases
SN - 0903-1936
IS - 3
ER -