Intrarenal arteriosclerosis and impairment of kidney function in NIDDM subjects

D. Boeri, L. E. Derchi, C. Martinoli, G. Simoni, L. Sampietro, D. Storace, L. Ponte, C. Calvi, M. Repetto, C. Robaudo, M. Maiello

Research output: Contribution to journalArticlepeer-review

Abstract

It is currently under debate whether the pathogenesis of end-stage renal failure in non-insulin-dependent diabetes mellitus (NIDDM) is a consequence of microangiopathy alone. The aim of this study was to investigate intrarenal arteriosclerosis and its correlation with kidney function in NIDDM. In 36 diabetic subjects, and in 10 age- and sex-matched healthy control subjects we measured kidney volume and resistive index of the interlobar arteries by duplex Doppler ultrasonography. Clinical and metabolic parameters, renal function and vascular sequelae of the disease were also evaluated. In diabetic subjects resistive index (median 0.72, range 0.54-0.79) was higher than in control subjects (median 0.62, range 0.57-0.66) (2p <0.002). Kidney volume and resistive index correlated with age (p <0.004), body mass index (p 1 (p

Original languageEnglish
Pages (from-to)121-124
Number of pages4
JournalDiabetologia
Volume41
Issue number1
DOIs
Publication statusPublished - 1998

Keywords

  • Albuminuria
  • Arteriosclerosis
  • Duplex Doppler ultrasonography
  • Kidney
  • Non-insulin-dependent diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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