Intraspinal Inclusion Tumor After Myelomeningocele Repair: A Long-Term Single-Center Experience

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: Given the lack of significant responses to many queries regarding behavior, treatment options, and possible prevention of iatrogenic intraspinal inclusion tumors (IITs), we think that further clinical, radiologic, and follow-up data are mandatory to better characterize this entity. We retrospectively reviewed a series of 14 consecutive patients with IIT occurring after myelomeningocele repair. The long follow-up is a mainstay of this series and may help a better understanding of the history of this slow-growing disease. To date, this is the largest series of IITs after myelomeningocele repair reported in the literature.

METHODS: A retrospective chart review was performed to identify all cases of surgically repaired myelomeningocele at the Department of Neurosurgery of G. Gaslini Children's Hospital in Genoa, from January 1993 to January 2018. Among them, data regarding patients in whom an IIT developed were recovered. The medical records of these patients and their clinical history, neurologic examination, and diagnostic workup were reviewed.

RESULTS: From January 1993 to January 2018, 160 cases of myelomeningocele were surgically treated. Among them, 14 cases of IIT developed. The mean time between myelomeningocele repair and IIT diagnosis was 94.7 months. The mean follow-up time was 60.1 months.

CONCLUSIONS: It is well established that IITs may be discovered in patients who have previously undergone myelomeningocele repair. In our series, with a long follow-up time, we describe the possible range of behavior of such lesions and the utility of surgical treatment of primary therapy. Our series confirms that residual IITs showed marked stability during our long follow-up.

Original languageEnglish
Pages (from-to)e1338-e1344
JournalWorld Neurosurg.
Publication statusPublished - Feb 2019


  • Adolescent
  • Child
  • Child, Preschool
  • Dermoid Cyst/etiology
  • Epidermal Cyst/etiology
  • Humans
  • Iatrogenic Disease
  • Magnetic Resonance Imaging
  • Meningomyelocele/surgery
  • Microsurgery/adverse effects
  • Musculoskeletal Pain/etiology
  • Neoplasm Seeding
  • Neurosurgical Procedures/adverse effects
  • Paresthesia/etiology
  • Postoperative Complications/etiology
  • Retrospective Studies
  • Spinal Neoplasms/etiology


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