Intrastriatal injection of D1 or D2 dopamine agonists affects glucose utilization in both the direct and indirect pathways of the rat basal ganglia

Giuseppe Conti, Fabio Blandini, Cristina Tassorelli, Franco Giubilei, Francesco Fornai, Alessandro Zocchi, Francesco Orzi

Research output: Contribution to journalArticlepeer-review

Abstract

Two distinct pathways are thought to connect the striatum to the basal ganglia output nuclei: a direct pathway, originating from neurons bearing dopamine, D1 receptors and an indirect pathway, originating from neurons expressing D2 receptors. It has been recently suggested, however, that dopamine receptor sub-types may co-localize and co-operate in the striatum. We sought to verify the functional segregation of the two pathways by measuring cerebral glucose utilization following intrastriatal injection of selective D1 (SKF 38393), D2 (quinpirole), or non-selective indirect (amphetamine) and direct (apomorphine) dopamine agonists, in freely-moving rats. All drugs - regardless of receptor selectivity - reduced glucose utilization in nuclei of both the direct and indirect pathways, thus lending further support to the existence of a functional co-operation of striatal D1 and D2 receptors.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalNeuroscience Letters
Volume309
Issue number3
DOIs
Publication statusPublished - Aug 31 2001

Keywords

  • Basal ganglia functional organization
  • D agonists
  • D agonists
  • Dopamine
  • Glucose metabolism

ASJC Scopus subject areas

  • Neuroscience(all)

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