Intrathecal application of autologous bone marrow cell preparations in Parkinsonian syndromes

Alexander Storch, Ilona Csoti, Karla Eggert, Tove Henriksen, Annika Plate, Michael Lorrain, Wolfgang H. Oertel, Angelo Antonini

Research output: Contribution to journalArticle

Abstract

Background: A growing number of patients is treated with intrathecal application of autologous bone marrow cells (aBMCs), but clinical data are completely lacking in movement disorders. We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes. Methods: Retrospective data collection from patients with parkinsonism who spontaneously sought cell treatment. The application procedure was neither recommended nor performed by the authors. Results: We report 17 patients with parkinsonian syndromes (Parkinson's disease [PD], n = 7; multiple system atrophy [MSA], n = 7; various, n = 3) who received intrathecal application of aBMCs. We did not observe any changes in motor function, activities of daily living, global clinical impression, or antiparkinsonian medication after a median observation period of 10 months. Two patients reported a worsening of parkinsonian symptoms, but the intervention was otherwise safe and well-tolerated. Conclusions: Intrathecal application of aBMCs in uncontrolled conditions produces no clinical benefit in parkinsonian syndromes.

Original languageEnglish
Pages (from-to)1552-1555
Number of pages4
JournalMovement Disorders
Volume27
Issue number12
DOIs
Publication statusPublished - Oct 2012

Keywords

  • Autologous transplantation
  • Bone marrow
  • CD34 cells
  • Intrathecal application
  • Mesenchymal stem cells
  • Mesodermal stromal cells
  • Multiple system atrophy
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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  • Cite this

    Storch, A., Csoti, I., Eggert, K., Henriksen, T., Plate, A., Lorrain, M., Oertel, W. H., & Antonini, A. (2012). Intrathecal application of autologous bone marrow cell preparations in Parkinsonian syndromes. Movement Disorders, 27(12), 1552-1555. https://doi.org/10.1002/mds.24920