Intrathecal baclofen application in patients with supraspinal spasticity secondary to severe traumatic brain injury

C. Rifici, M. Kofler, M. Kronenberg, A. Kofler, P. Bramanti, L. Saltuari

Research output: Contribution to journalArticle

Abstract

Intrathecal application of baclofen is considered the treatment of choice in patients suffering from spinal spasticity insufficiently responding to conventional oral antispastic medication. This approach has also been used successfully in cases with spasticity of supraspinal origin. To achieve a good therapeutic response in the latter condition the amount of intrathecal baclofen has to be approximately twice the dosage required in spinal spasticity. We report on 8 patients suffering from supraspinal spasticity due to severe traumatic brain injury. Intrathecal baclofen reduced spasticity in all patients (mean Ashworth Score from 3.9 to 1.6; mean Reflex Score from 4.0 to 1.4). In some cases improvement of motor performance and in one case recovery of bladder function were noted. In two patients focal epileptic seizures with secondary generalization seemed to be associated with the application of baclofen. The local intrathecal application of baclofen has proven to be an effective therapy in otherwise intractable cases of severe supraspinal spasticity.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalFunctional Neurology
Volume9
Issue number1
Publication statusPublished - 1994

Fingerprint

Baclofen
Recovery of Function
Reflex
Epilepsy
Urinary Bladder
Seizures
Therapeutics
Traumatic Brain Injury

Keywords

  • intrathecal baclofen
  • supraspinal spasticity
  • traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Intrathecal baclofen application in patients with supraspinal spasticity secondary to severe traumatic brain injury. / Rifici, C.; Kofler, M.; Kronenberg, M.; Kofler, A.; Bramanti, P.; Saltuari, L.

In: Functional Neurology, Vol. 9, No. 1, 1994, p. 29-34.

Research output: Contribution to journalArticle

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