Abstract
We report the case of a 27-year-male who developed a rapidly progressive involvement of multiple cranial nerves together with signs/symptoms of widespread radicular disease at all spinal cord levels; search for infectious, inflammatory and autoimmune disorders was negative, as well as screening for occult tumor in non-CNS sites (including bone marrow biopsy). Cerebrospinal fluid analysis - initially disclosing mild lymphocytic pleocytosis - allowed diagnosis after steroid withdrawal (2 months from onset), showing 1600 cells/mm3, low glucose and presence of monoclonal B-lymphocytic expansion limited to the CSF. Despite high-dose methotrexate therapy and 1 cycle of Ara-C, the patients' conditions progressively deteriorated leading to the exitus. This case shows the peculiarity of a lymphoproliferative disorder with an intrathecal localization and only a negligible involvement of PB (increase in percentage of CD20 and CD19 positive cells).
Translated title of the contribution | Intrathecal dissemination of a lymphomatous meningoradicolitis: Clinical case report |
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Original language | Italian |
Pages (from-to) | 221-226 |
Number of pages | 6 |
Journal | Rivista Italiana di Neurobiologia |
Volume | 3 |
Issue number | 3-4 |
Publication status | Published - 2006 |
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)