Abstract
We report the case of a 27-year-male who developed a rapidly progressive involvement of multiple cranial nerves together with signs/symptoms of widespread radicular disease at all spinal cord levels; search for infectious, inflammatory and autoimmune disorders was negative, as well as screening for occult tumor in non-CNS sites (including bone marrow biopsy). Cerebrospinal fluid analysis - initially disclosing mild lymphocytic pleocytosis - allowed diagnosis after steroid withdrawal (2 months from onset), showing 1600 cells/mm3, low glucose and presence of monoclonal B-lymphocytic expansion limited to the CSF. Despite high-dose methotrexate therapy and 1 cycle of Ara-C, the patients' conditions progressively deteriorated leading to the exitus. This case shows the peculiarity of a lymphoproliferative disorder with an intrathecal localization and only a negligible involvement of PB (increase in percentage of CD20 and CD19 positive cells).
| Original language | Italian |
|---|---|
| Pages (from-to) | 221-226 |
| Number of pages | 6 |
| Journal | Rivista Italiana di Neurobiologia |
| Volume | 3 |
| Issue number | 3-4 |
| Publication status | Published - 2006 |
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ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Disseminazione intratecale di meningoradicolite linfomatosa : Descrizione di un caso clinico. / Corsini, Elena; Ciusani, Emilio; Bernardi, Gaetano; Calatozzolo, Chiara; Balzarotti, Marco; Boiardi, Amerigo; Croci, Danilo; Botturi, Andrea; Erbetta, Alessandra; Salmaggi, Andrea.
In: Rivista Italiana di Neurobiologia, Vol. 3, No. 3-4, 2006, p. 221-226.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Disseminazione intratecale di meningoradicolite linfomatosa
T2 - Descrizione di un caso clinico
AU - Corsini, Elena
AU - Ciusani, Emilio
AU - Bernardi, Gaetano
AU - Calatozzolo, Chiara
AU - Balzarotti, Marco
AU - Boiardi, Amerigo
AU - Croci, Danilo
AU - Botturi, Andrea
AU - Erbetta, Alessandra
AU - Salmaggi, Andrea
PY - 2006
Y1 - 2006
N2 - We report the case of a 27-year-male who developed a rapidly progressive involvement of multiple cranial nerves together with signs/symptoms of widespread radicular disease at all spinal cord levels; search for infectious, inflammatory and autoimmune disorders was negative, as well as screening for occult tumor in non-CNS sites (including bone marrow biopsy). Cerebrospinal fluid analysis - initially disclosing mild lymphocytic pleocytosis - allowed diagnosis after steroid withdrawal (2 months from onset), showing 1600 cells/mm3, low glucose and presence of monoclonal B-lymphocytic expansion limited to the CSF. Despite high-dose methotrexate therapy and 1 cycle of Ara-C, the patients' conditions progressively deteriorated leading to the exitus. This case shows the peculiarity of a lymphoproliferative disorder with an intrathecal localization and only a negligible involvement of PB (increase in percentage of CD20 and CD19 positive cells).
AB - We report the case of a 27-year-male who developed a rapidly progressive involvement of multiple cranial nerves together with signs/symptoms of widespread radicular disease at all spinal cord levels; search for infectious, inflammatory and autoimmune disorders was negative, as well as screening for occult tumor in non-CNS sites (including bone marrow biopsy). Cerebrospinal fluid analysis - initially disclosing mild lymphocytic pleocytosis - allowed diagnosis after steroid withdrawal (2 months from onset), showing 1600 cells/mm3, low glucose and presence of monoclonal B-lymphocytic expansion limited to the CSF. Despite high-dose methotrexate therapy and 1 cycle of Ara-C, the patients' conditions progressively deteriorated leading to the exitus. This case shows the peculiarity of a lymphoproliferative disorder with an intrathecal localization and only a negligible involvement of PB (increase in percentage of CD20 and CD19 positive cells).
KW - CSF dissemination
KW - Cytology
KW - Flow cytometry
KW - Lymphoma
UR - http://www.scopus.com/inward/record.url?scp=77952036022&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952036022&partnerID=8YFLogxK
M3 - Articolo
VL - 3
SP - 221
EP - 226
JO - Rivista Italiana di Neurobiologia
JF - Rivista Italiana di Neurobiologia
SN - 0035-6336
IS - 3-4
ER -