Intrathecal immune activation in three patients with progressive myoclonic ataxia

A. Salmaggi, F. Carella, C. Ciano, S. Binelli, P. Giovannini, E. Palazzini, F. Girotti

Research output: Contribution to journalArticlepeer-review


Three patients displaying a clinical picture of progressively evolving multifocal action myoclonus and cerebellar ataxia showed a marked intrathecal immune activation, which was persistent over a 2- to 5-year time span in the two serially investigated patients. A thorough search for metabolic, toxic, infectious, or degenerative causes of myoclonus was unsuccessful. The presence of intrathecal immune activation in at least a subgroup of patients with the clinical features of progressive myoclonic ataxia suggests the possibility of immune-mediated damage within the central nervous system in this condition.

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalMovement Disorders
Issue number2
Publication statusPublished - 1995


  • Cerebellar ataxia
  • Intrathecal immune activation
  • Multiple action myoclonus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


Dive into the research topics of 'Intrathecal immune activation in three patients with progressive myoclonic ataxia'. Together they form a unique fingerprint.

Cite this