Abstract
Three patients displaying a clinical picture of progressively evolving multifocal action myoclonus and cerebellar ataxia showed a marked intrathecal immune activation, which was persistent over a 2- to 5-year time span in the two serially investigated patients. A thorough search for metabolic, toxic, infectious, or degenerative causes of myoclonus was unsuccessful. The presence of intrathecal immune activation in at least a subgroup of patients with the clinical features of progressive myoclonic ataxia suggests the possibility of immune-mediated damage within the central nervous system in this condition.
| Original language | English |
|---|---|
| Pages (from-to) | 207-210 |
| Number of pages | 4 |
| Journal | Movement Disorders |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1995 |
Keywords
- Cerebellar ataxia
- Intrathecal immune activation
- Multiple action myoclonus
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
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Salmaggi, A., Carella, F., Ciano, C., Binelli, S., Giovannini, P., Palazzini, E., & Girotti, F. (1995). Intrathecal immune activation in three patients with progressive myoclonic ataxia. Movement Disorders, 10(2), 207-210. https://doi.org/10.1002/mds.870100212