Intrathecal immune activation in three patients with progressive myoclonic ataxia

A. Salmaggi; F. Carella; C. Ciano; S. Binelli; P. Giovannini; E. Palazzini; F. Girotti

doi:10.1002/mds.870100212

Intrathecal immune activation in three patients with progressive myoclonic ataxia

A. Salmaggi, F. Carella, C. Ciano, S. Binelli, P. Giovannini, E. Palazzini, F. Girotti

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

Three patients displaying a clinical picture of progressively evolving multifocal action myoclonus and cerebellar ataxia showed a marked intrathecal immune activation, which was persistent over a 2- to 5-year time span in the two serially investigated patients. A thorough search for metabolic, toxic, infectious, or degenerative causes of myoclonus was unsuccessful. The presence of intrathecal immune activation in at least a subgroup of patients with the clinical features of progressive myoclonic ataxia suggests the possibility of immune-mediated damage within the central nervous system in this condition.

Original language	English
Pages (from-to)	207-210
Number of pages	4
Journal	Movement Disorders
Volume	10
Issue number	2
DOIs	https://doi.org/10.1002/mds.870100212
Publication status	Published - 1995

Keywords

Cerebellar ataxia
Intrathecal immune activation
Multiple action myoclonus

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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10.1002/mds.870100212

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abstract = "Three patients displaying a clinical picture of progressively evolving multifocal action myoclonus and cerebellar ataxia showed a marked intrathecal immune activation, which was persistent over a 2- to 5-year time span in the two serially investigated patients. A thorough search for metabolic, toxic, infectious, or degenerative causes of myoclonus was unsuccessful. The presence of intrathecal immune activation in at least a subgroup of patients with the clinical features of progressive myoclonic ataxia suggests the possibility of immune-mediated damage within the central nervous system in this condition.",

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AU - Salmaggi, A.

AU - Carella, F.

AU - Ciano, C.

AU - Binelli, S.

AU - Giovannini, P.

AU - Palazzini, E.

AU - Girotti, F.

PY - 1995

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N2 - Three patients displaying a clinical picture of progressively evolving multifocal action myoclonus and cerebellar ataxia showed a marked intrathecal immune activation, which was persistent over a 2- to 5-year time span in the two serially investigated patients. A thorough search for metabolic, toxic, infectious, or degenerative causes of myoclonus was unsuccessful. The presence of intrathecal immune activation in at least a subgroup of patients with the clinical features of progressive myoclonic ataxia suggests the possibility of immune-mediated damage within the central nervous system in this condition.

AB - Three patients displaying a clinical picture of progressively evolving multifocal action myoclonus and cerebellar ataxia showed a marked intrathecal immune activation, which was persistent over a 2- to 5-year time span in the two serially investigated patients. A thorough search for metabolic, toxic, infectious, or degenerative causes of myoclonus was unsuccessful. The presence of intrathecal immune activation in at least a subgroup of patients with the clinical features of progressive myoclonic ataxia suggests the possibility of immune-mediated damage within the central nervous system in this condition.

KW - Cerebellar ataxia

KW - Intrathecal immune activation

KW - Multiple action myoclonus

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Intrathecal immune activation in three patients with progressive myoclonic ataxia

Abstract

Keywords

ASJC Scopus subject areas

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