Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system

Paolo Gallo, Susanna Sivieri, Luciano Rinaldi, Xiao Bo Yan, Francesco Lolli, Anita De Rossi, Bruno Tavolato

Research output: Contribution to journalArticle

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Abstract

The intrathecal synthesis of interleukin 10 (IL-10) was investigated in 120 paired cerebrospinal fluid (CSF) and scrum specimens from patients with various inflammatory and non-inflammatory diseases of the central nervous system (CNS). IL-10 was not demonstrated in the sera, but detectable levels were found in the CSF from: patients with acute viral ("aseptic") meningitis, but only within 48-72 h of symptom onset; human immunodeficiency virus type 1 (HIV)-infected patients with HIV-related encephalitis/leukoencephalopathy or cryptococcal meningitis; a patient with primary B cell lymphoma of the CNS, and a patient with encephalomeningeal sarcoidosis (in whom IL-10 was demonstrated in all CSF collected over a period of 6-months). In chronic meningeal infections/inflammations, IL-10 seems to be continuously produced within the CSF. Our findings suggest that IL-10, a cytokine which exerts many immunosuppressive actions, may play different immunomodulatory roles in CNS diseases; in particular, its intrathecal synthesis may explain why some infectious and inflammatory meningeal diseases may have slow development and chronic evolution.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalJournal of the Neurological Sciences
Volume126
Issue number1
DOIs
Publication statusPublished - 1994

Fingerprint

Central Nervous System Viral Diseases
Interleukin-10
Cerebrospinal Fluid
Central Nervous System Diseases
HIV-1
Viral Meningitis
Cryptococcal Meningitis
Aseptic Meningitis
Leukoencephalopathies
B-Cell Lymphoma
Encephalitis
Immunosuppressive Agents
Sarcoidosis
Central Nervous System
Cytokines
Inflammation
Infection
Serum

Keywords

  • Cerebrospinal fluid
  • HIV
  • Interleukin-10
  • Neurological diseases

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system. / Gallo, Paolo; Sivieri, Susanna; Rinaldi, Luciano; Yan, Xiao Bo; Lolli, Francesco; De Rossi, Anita; Tavolato, Bruno.

In: Journal of the Neurological Sciences, Vol. 126, No. 1, 1994, p. 49-53.

Research output: Contribution to journalArticle

Gallo, Paolo ; Sivieri, Susanna ; Rinaldi, Luciano ; Yan, Xiao Bo ; Lolli, Francesco ; De Rossi, Anita ; Tavolato, Bruno. / Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system. In: Journal of the Neurological Sciences. 1994 ; Vol. 126, No. 1. pp. 49-53.
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