Abstract
The intrathecal synthesis of interleukin 10 (IL-10) was investigated in 120 paired cerebrospinal fluid (CSF) and scrum specimens from patients with various inflammatory and non-inflammatory diseases of the central nervous system (CNS). IL-10 was not demonstrated in the sera, but detectable levels were found in the CSF from: patients with acute viral ("aseptic") meningitis, but only within 48-72 h of symptom onset; human immunodeficiency virus type 1 (HIV)-infected patients with HIV-related encephalitis/leukoencephalopathy or cryptococcal meningitis; a patient with primary B cell lymphoma of the CNS, and a patient with encephalomeningeal sarcoidosis (in whom IL-10 was demonstrated in all CSF collected over a period of 6-months). In chronic meningeal infections/inflammations, IL-10 seems to be continuously produced within the CSF. Our findings suggest that IL-10, a cytokine which exerts many immunosuppressive actions, may play different immunomodulatory roles in CNS diseases; in particular, its intrathecal synthesis may explain why some infectious and inflammatory meningeal diseases may have slow development and chronic evolution.
| Original language | English |
|---|---|
| Pages (from-to) | 49-53 |
| Number of pages | 5 |
| Journal | Journal of the Neurological Sciences |
| Volume | 126 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1994 |
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Keywords
- Cerebrospinal fluid
- HIV
- Interleukin-10
- Neurological diseases
ASJC Scopus subject areas
- Ageing
- Clinical Neurology
- Surgery
- Neuroscience(all)
- Developmental Neuroscience
- Neurology
Cite this
Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system. / Gallo, Paolo; Sivieri, Susanna; Rinaldi, Luciano; Yan, Xiao Bo; Lolli, Francesco; De Rossi, Anita; Tavolato, Bruno.
In: Journal of the Neurological Sciences, Vol. 126, No. 1, 1994, p. 49-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system
AU - Gallo, Paolo
AU - Sivieri, Susanna
AU - Rinaldi, Luciano
AU - Yan, Xiao Bo
AU - Lolli, Francesco
AU - De Rossi, Anita
AU - Tavolato, Bruno
PY - 1994
Y1 - 1994
N2 - The intrathecal synthesis of interleukin 10 (IL-10) was investigated in 120 paired cerebrospinal fluid (CSF) and scrum specimens from patients with various inflammatory and non-inflammatory diseases of the central nervous system (CNS). IL-10 was not demonstrated in the sera, but detectable levels were found in the CSF from: patients with acute viral ("aseptic") meningitis, but only within 48-72 h of symptom onset; human immunodeficiency virus type 1 (HIV)-infected patients with HIV-related encephalitis/leukoencephalopathy or cryptococcal meningitis; a patient with primary B cell lymphoma of the CNS, and a patient with encephalomeningeal sarcoidosis (in whom IL-10 was demonstrated in all CSF collected over a period of 6-months). In chronic meningeal infections/inflammations, IL-10 seems to be continuously produced within the CSF. Our findings suggest that IL-10, a cytokine which exerts many immunosuppressive actions, may play different immunomodulatory roles in CNS diseases; in particular, its intrathecal synthesis may explain why some infectious and inflammatory meningeal diseases may have slow development and chronic evolution.
AB - The intrathecal synthesis of interleukin 10 (IL-10) was investigated in 120 paired cerebrospinal fluid (CSF) and scrum specimens from patients with various inflammatory and non-inflammatory diseases of the central nervous system (CNS). IL-10 was not demonstrated in the sera, but detectable levels were found in the CSF from: patients with acute viral ("aseptic") meningitis, but only within 48-72 h of symptom onset; human immunodeficiency virus type 1 (HIV)-infected patients with HIV-related encephalitis/leukoencephalopathy or cryptococcal meningitis; a patient with primary B cell lymphoma of the CNS, and a patient with encephalomeningeal sarcoidosis (in whom IL-10 was demonstrated in all CSF collected over a period of 6-months). In chronic meningeal infections/inflammations, IL-10 seems to be continuously produced within the CSF. Our findings suggest that IL-10, a cytokine which exerts many immunosuppressive actions, may play different immunomodulatory roles in CNS diseases; in particular, its intrathecal synthesis may explain why some infectious and inflammatory meningeal diseases may have slow development and chronic evolution.
KW - Cerebrospinal fluid
KW - HIV
KW - Interleukin-10
KW - Neurological diseases
UR - http://www.scopus.com/inward/record.url?scp=0028101105&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028101105&partnerID=8YFLogxK
U2 - 10.1016/0022-510X(94)90093-0
DO - 10.1016/0022-510X(94)90093-0
M3 - Article
C2 - 7836946
AN - SCOPUS:0028101105
VL - 126
SP - 49
EP - 53
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 1
ER -