Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system

Paolo Gallo, Susanna Sivieri, Luciano Rinaldi, Xiao Bo Yan, Francesco Lolli, Anita De Rossi, Bruno Tavolato

Research output: Contribution to journalArticlepeer-review


The intrathecal synthesis of interleukin 10 (IL-10) was investigated in 120 paired cerebrospinal fluid (CSF) and scrum specimens from patients with various inflammatory and non-inflammatory diseases of the central nervous system (CNS). IL-10 was not demonstrated in the sera, but detectable levels were found in the CSF from: patients with acute viral ("aseptic") meningitis, but only within 48-72 h of symptom onset; human immunodeficiency virus type 1 (HIV)-infected patients with HIV-related encephalitis/leukoencephalopathy or cryptococcal meningitis; a patient with primary B cell lymphoma of the CNS, and a patient with encephalomeningeal sarcoidosis (in whom IL-10 was demonstrated in all CSF collected over a period of 6-months). In chronic meningeal infections/inflammations, IL-10 seems to be continuously produced within the CSF. Our findings suggest that IL-10, a cytokine which exerts many immunosuppressive actions, may play different immunomodulatory roles in CNS diseases; in particular, its intrathecal synthesis may explain why some infectious and inflammatory meningeal diseases may have slow development and chronic evolution.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalJournal of the Neurological Sciences
Issue number1
Publication statusPublished - 1994


  • Cerebrospinal fluid
  • HIV
  • Interleukin-10
  • Neurological diseases

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology


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