Intrathoracic and ventricular impedances are associated with changes in ventricular volume in patients receiving defibrillators for CRT

Massimiliano Maines, Maurizio Landolina, Maurizio Lunati, Gabriele Lonardi, Alessia Pappone, Alessandro Proclemer, Gabriele Zanotto, Massimo Santini, Annamaria Varbaro, Marco Vimercati, Sergio Valsecchi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Some implantable cardioverter defibrillators (ICD) are able to monitor intrathoracic impedance to detect pulmonary fluid overload. This is achieved by measuring impedance between the ICD case and the right ventricular (RV) lead. We hypothesized that the measured impedance would rise with improvement in left ventricular (LV) volumes during cardiac resynchronization therapy (CRT), and that such impedance changes would be more apparent when measured with an alternative pacing vector. Methods: We analyzed echocardiographic and impedance data from heart failure patients implanted with a CRT-ICD capable of intrathoracic impedance measurement for fluid accumulation diagnosis, and LV pacing impedance recording for lead integrity monitoring. Results: In 127 out of 170 patients that received de novo CRT implantation, the LV end-systolic volume (LVESV) decreased at 6-month follow-up (LVESV at 6 month - LVESV at baseline

Original languageEnglish
Pages (from-to)64-73
Number of pages10
JournalPACE - Pacing and Clinical Electrophysiology
Volume33
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Heart failure
  • Impedance implantable defibrillator
  • Ventricular volume

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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