TY - JOUR
T1 - Intratumor heterogeneity and its impact on drug distribution and sensitivity
AU - Fuso Nerini, I.
AU - Morosi, L.
AU - Zucchetti, M.
AU - Ballerini, A.
AU - Giavazzi, R.
AU - D'incalci, M.
PY - 2014
Y1 - 2014
N2 - We provide an overview of the available information on the distribution of chemotherapeutics in human tumors, highlighting the progress made to assess the heterogeneity of drug concentrations in relation to the complex neoplastic tissue using novel analytical methods, e.g., mass spectrometry imaging. The increase in interstitial fluid pressure due to abnormal vascularization and stiffness of tumor stroma explains the variable and heterogeneous drug concentrations. Therapeutic strategies to enhance tumor drug distribution, thus possibly increasing efficacy, are discussed.
AB - We provide an overview of the available information on the distribution of chemotherapeutics in human tumors, highlighting the progress made to assess the heterogeneity of drug concentrations in relation to the complex neoplastic tissue using novel analytical methods, e.g., mass spectrometry imaging. The increase in interstitial fluid pressure due to abnormal vascularization and stiffness of tumor stroma explains the variable and heterogeneous drug concentrations. Therapeutic strategies to enhance tumor drug distribution, thus possibly increasing efficacy, are discussed.
UR - http://www.scopus.com/inward/record.url?scp=84904856656&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904856656&partnerID=8YFLogxK
U2 - 10.1038/clpt.2014.105
DO - 10.1038/clpt.2014.105
M3 - Article
C2 - 24827540
AN - SCOPUS:84904856656
VL - 96
SP - 224
EP - 238
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
SN - 0009-9236
IS - 2
ER -