Intratumour amount of sex steroids in elderly breast cancer patients. An approach to the biological characterization of mammary tumours in the elderly

G. Secreto, E. Venturelli, A. Bucci, D. Piromalli, G. Fariselli, E. Galante

Research output: Contribution to journalArticle

Abstract

Interest in breast cancer in elderly women is growing as a result of the high frequency of cancer in older age groups. We measured tumour concentrations and circulating levels of testosterone, dihydrotestosterone (DHT) and oestradiol in 50 postmenopausal patients: 26 younger than 70 yr (median, 61.5, range 50-69) and 24 older than 70 yr (median, 74.5, range 70-82). Hormones were measured by radioimmunoassay (RIA) after extraction and separation on celite column chromatography. Intratumour levels of the three steroids were lower in the older than in the younger patients, but the difference was statistically significant only for DHT (P= 0.0126). The decrease in the tumour concentrations of testosterone and DHT in the older group was associated with a slight increase in circulating levels, yielding as final result a statistically significant decrease of the tissue/plasma (T/P) ratio of these hormones. No significant difference was observed between groups for oestradiol levels. The blood levels of testosterone, DHT and oestradiol were significantly correlated in the older group, but not in the younger group. In contrast, the tumour amounts of testosterone and DHT were found to be significantly associated only in the

Original languageEnglish
Pages (from-to)557-561
Number of pages5
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume58
Issue number5-6
Publication statusPublished - 1996

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Dihydrotestosterone
Tumors
Steroids
Testosterone
Breast Neoplasms
Estradiol
Neoplasms
Hormones
Diatomaceous Earth
Column chromatography
Radioimmunoassay
Chromatography
Blood
Age Groups
Tissue
Plasmas

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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Intratumour amount of sex steroids in elderly breast cancer patients. An approach to the biological characterization of mammary tumours in the elderly. / Secreto, G.; Venturelli, E.; Bucci, A.; Piromalli, D.; Fariselli, G.; Galante, E.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 58, No. 5-6, 1996, p. 557-561.

Research output: Contribution to journalArticle

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AU - Fariselli, G.

AU - Galante, E.

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