Intrauterine device use and risk of endometrial cancer

F. Parazzini, C. La Vecchia, S. Moroni

Research output: Contribution to journalArticlepeer-review


The relationship between intrauterine device (IUD) use and risk of endometrial cancer has been analysed in a case-control study conducted in Italy between 1983 and 1992, including 453 patients with histologically confirmed endometrial cancer and 1,451 controls admitted for acute, non-gynaecological, nonhormonal, non-neoplastic conditions to the same network of hospitals where cases had been identified. Two (0.4%) cases versus 36 (2.3%) controls reported ever using an IUD. The corresponding multivariate relative risk was 0.4 (95% Cl 0.1-1.0). The results of this study and the few published available epidemiological data suggest a protective role of IUD use on endometrial carcinogenesis, but potential selective mechanisms for IUD utilisation (indication bias) should be carefully considered in the interpretation.

Original languageEnglish
Pages (from-to)672-673
Number of pages2
JournalBritish Journal of Cancer
Issue number4
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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