Intrauterine growth in the offspring of epileptic mothers

D. Battino, T. Granata, S. Binelli, M. L. Caccamo, M. P. Canevini, R. Canger, D. Croci, C. Fumarola, R. Mai, F. Molteni, G. Pardi, G. Avanzini

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The present paper concerns the fetal growth of 315 newborns of epileptic mothers prospectively followed from the beginning of pregnancy. In comparison with Italian standards, neonatal weight, length and head circumference at birth were below the 10th percentile in respectively 15.7%, 1.1% and 19.2% of the newborns. Weight at birth was above the 90th percentile in 8 cases. Observed frequencies were significantly higher than expected frequencies for both weight and head circumference. The percentage of newborns with a small head circumference increased significantly according to the number of drugs taken by the mother during the first three months of pregnancy: 7.1% with no drug, 16.8% with one drug, 23.6% with two drugs and 50% with three drugs. A statistically significant correlation was found between gestational age-adjusted head circumference and drug-level scores during the first trimester. Head circumferences below the 10th percentile were fewer among newborns treated with CBZ than among newborns treated with either PB or VPA.

Original languageEnglish
Pages (from-to)555-557
Number of pages3
JournalActa Neurologica Scandinavica
Volume86
Issue number6
Publication statusPublished - 1992

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Head
Growth
Pharmaceutical Preparations
Weights and Measures
Pregnancy
First Pregnancy Trimester
Fetal Development
Birth Weight
Gestational Age
Parturition

Keywords

  • antiepileptic drugs
  • epilepsy
  • head circumference
  • intrauterine growth

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Battino, D., Granata, T., Binelli, S., Caccamo, M. L., Canevini, M. P., Canger, R., ... Avanzini, G. (1992). Intrauterine growth in the offspring of epileptic mothers. Acta Neurologica Scandinavica, 86(6), 555-557.

Intrauterine growth in the offspring of epileptic mothers. / Battino, D.; Granata, T.; Binelli, S.; Caccamo, M. L.; Canevini, M. P.; Canger, R.; Croci, D.; Fumarola, C.; Mai, R.; Molteni, F.; Pardi, G.; Avanzini, G.

In: Acta Neurologica Scandinavica, Vol. 86, No. 6, 1992, p. 555-557.

Research output: Contribution to journalArticle

Battino, D, Granata, T, Binelli, S, Caccamo, ML, Canevini, MP, Canger, R, Croci, D, Fumarola, C, Mai, R, Molteni, F, Pardi, G & Avanzini, G 1992, 'Intrauterine growth in the offspring of epileptic mothers', Acta Neurologica Scandinavica, vol. 86, no. 6, pp. 555-557.
Battino, D. ; Granata, T. ; Binelli, S. ; Caccamo, M. L. ; Canevini, M. P. ; Canger, R. ; Croci, D. ; Fumarola, C. ; Mai, R. ; Molteni, F. ; Pardi, G. ; Avanzini, G. / Intrauterine growth in the offspring of epileptic mothers. In: Acta Neurologica Scandinavica. 1992 ; Vol. 86, No. 6. pp. 555-557.
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