Intravascular immunity as a key to systemic vasculitis: A work in progress, gaining momentum

G. A. Ramirez, N. Maugeri, M. G. Sabbadini, P. Rovere-Querini, A. A. Manfredi

Research output: Contribution to journalArticlepeer-review

Abstract

Vascular inflammation contributes to the defence against invading microbes and to the repair of injured tissues. In most cases it resolves before becoming apparent. Vasculitis comprises heterogeneous clinical entities that are characterized by the persistence of vascular inflammation after it has served its homeostatic function. Most underlying mechanisms have so far remained elusive. Intravascular immunity refers to the surveillance of the vasculature by leucocytes that sense microbial or sterile threats to vessel integrity and initiate protective responses that entail most events that determine the clinical manifestations of vasculitis, such as end-organ ischaemia, neutrophil extracellular traps generation and thrombosis, leucocyte extravasation and degranulation. Understanding how the resolution of vascular inflammation goes awry in patients with systemic vasculitis will facilitate the identification of novel pharmacological targets and bring us a step closer in each patient to the selection of more effective and less toxic treatments.

Original languageEnglish
Pages (from-to)150-166
Number of pages17
JournalClinical and Experimental Immunology
Volume175
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Intravascular immunity
  • Pathogenesis
  • Thrombosis
  • Treatment
  • Vasculitis
  • Vessel inflammation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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