Intravascular ultrasound findings in the multicenter, randomized, double-blind RAVEL (RAndomized study with the sirolimus-eluting VElocity balloon-expandable stent in the treatment of patients with de novo native coronary artery lesions) trial

Patrick W. Serruys, Muzaffer Degertekin, Kengo Tanabe, Alexandre Abizaid, J. Edouardo Sousa, Antonio Colombo, Giulio Guagliumi, William Wijns, Wietze K. Lindeboom, Jurgen Ligthart, Pim J. De Feyter, Marie Claude Morice

Research output: Contribution to journalArticle

Abstract

Background - The goal of this intravascular ultrasound investigation was to provide a more detailed morphological analysis of the local biological effects of the implantation of a sirolimus-eluting stent compared with an uncoated stent. Methods and Results - In the RAVEL trial, 238 patients with single de novo lesions were randomized to receive either an 18-mm sirolimus-eluting stent (Bx VELOCITY stent, Cordis) or an uncoated stent (Bx VELOCITY stent). In a subset of 95 patients (sirolimus-eluting stent=48, uncoated stent=47), motorized intravascular ultrasound pullback (0.5 mm/s) was performed at a 6-month follow-up. Stent volumes, total vessel volumes, and plaque-behind-stent volumes were comparable. However, the difference in neointimal hyperplasia (2±5 versus 37±28 mm3) and percent of volume obstruction (1±3% versus 29±20%) at 6 months between the 2 groups was highly significant (P

Original languageEnglish
Pages (from-to)798-803
Number of pages6
JournalCirculation
Volume106
Issue number7
DOIs
Publication statusPublished - Aug 13 2002

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Keywords

  • Drugs
  • Restenosis
  • Stents
  • Ultrasonics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Serruys, P. W., Degertekin, M., Tanabe, K., Abizaid, A., Sousa, J. E., Colombo, A., Guagliumi, G., Wijns, W., Lindeboom, W. K., Ligthart, J., De Feyter, P. J., & Morice, M. C. (2002). Intravascular ultrasound findings in the multicenter, randomized, double-blind RAVEL (RAndomized study with the sirolimus-eluting VElocity balloon-expandable stent in the treatment of patients with de novo native coronary artery lesions) trial. Circulation, 106(7), 798-803. https://doi.org/10.1161/01.CIR.0000025585.63486.59